Authors:	Mier, Pablo Pérez-Pulido, Antonio J. Reynaud, Emmanuel G. Andrade, Miguel
Title:	Reading the evolution of compartmentalization in the ribosome assembly toolbox : the YRG protein family
Online publication date:	13-Oct-2022
Year of first publication:	2017
Language:	english
Abstract:	Reconstructing the transition from a single compartment bacterium to a highly compartmentalized eukaryotic cell is one of the most studied problems of evolutionary cell biology. However, timing and details of the establishment of compartmentalization are unclear and difficult to assess. Here, we propose the use of molecular markers specific to cellular compartments to set up a framework to advance the understanding of this complex intracellular process. Specifically, we use a protein family related to ribosome biogenesis, YRG (YlqF related GTPases), whose evolution is linked to the establishment of cellular compartments, leveraging the current genomic data. We analyzed orthologous proteins of the YRG family in a set of 171 proteomes for a total of 370 proteins. We identified ten YRG protein subfamilies that can be associated to six subcellular compartments (nuclear bodies, nucleolus, nucleus, cytosol, mitochondria, and chloroplast), and which were found in archaeal, bacterial and eukaryotic proteomes. Our analysis reveals organism streamlining related events in specific taxonomic groups such as Fungi. We conclude that the YRG family could be used as a compartmentalization marker, which could help to trace the evolutionary path relating cellular compartments with ribosome biogenesis.
DDC:	570 Biowissenschaften 570 Life sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 10 Biologie
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7979
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	PLoS one 12 1
Pages or article number:	e0169750
Publisher:	PLoS
Publisher place:	Lawrence, Kan.
Issue date:	2017
ISSN:	1932-6203
Publisher URL:	http://dx.doi.org/10.1371/journal.pone.0169750
Publisher DOI:	10.1371/journal.pone.0169750
Annotation:	Andrade, Miguel veröffentlicht unter: Andrade-Navarro, Miguel A.
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)