Gutenberg Open Science: Characterization of the human aqueous humour proteome : a comparison of the genders

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7975

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DC Field	Value	Language
dc.contributor.author	Perumal, Natarajan	-
dc.contributor.author	Manicam, Caroline	-
dc.contributor.author	Steinicke, Matthias	-
dc.contributor.author	Funke, Sebastian	-
dc.contributor.author	Pfeiffer, Norbert	-
dc.contributor.author	Grus, Franz-Hermann	-
dc.date.accessioned	2022-10-13T09:16:50Z	-
dc.date.available	2022-10-13T09:16:50Z	-
dc.date.issued	2017
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7990	-
dc.description.abstract	Aqueous humour (AH) is an important biologic fluid that maintains normal intraocular pressure and contains proteins that regulate the homeostasis of ocular tissues. Any alterations in the protein compositions are correlated to the pathogenesis of various ocular disorders. In recent years, gender-based medicine has emerged as an important research focus considering the prevalence of certain diseases, which are higher in a particular sex. Nevertheless, the inter-gender variations in the AH proteome are unknown. Therefore, this study endeavoured to characterize the AH proteome to assess the differences between genders. Thirty AH samples of patients who underwent cataract surgery were categorized according to their gender. Label-free quantitative discovery mass spectrometry-based proteomics strategy was employed to characterize the AH proteome. A total of 147 proteins were identified with a false discovery rate of less than 1% and only the top 10 major AH proteins make up almost 90% of the total identified proteins. A large number of proteins identified were correlated to defence, immune and inflammatory mechanisms, and response to wounding. Four proteins were found to be differentially abundant between the genders, comprising SERPINF1, SERPINA3, SERPING1 and PTGDS. The findings emerging from our study provide the first insight into the gender-based proteome differences in the AH and also highlight the importance in considering potential sex-dependent changes in the proteome of ocular pathologies in future studies employing the AH.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Characterization of the human aqueous humour proteome : a comparison of the genders	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7975	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	PLOS ONE	de
jgu.journal.volume	12	de
jgu.journal.issue	3	de
jgu.pages.alternative	e0172481	de
jgu.publisher.year	2017	-
jgu.publisher.name	PLOS	de
jgu.publisher.place	San Francisco, California, US	de
jgu.publisher.uri	http://dx.doi.org/10.1371/journal.pone.0172481	de
jgu.publisher.issn	1932-6203	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2018-03-12T11:53:33Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 04: Medizin: Augenklinik und Poliklinik	de_DE
opus.identifier.opusid	57966
opus.institute.number	0446
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Pfeiffer, Norbert
opus.affiliated	Grus, Franz-Hermann
jgu.publisher.doi	10.1371/journal.pone.0172481	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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