Gutenberg Open Science: IL-10 control of CD11c+ myeloid cells is essential to maintain immune homeostasis in the small and large intestine

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7921

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DC Field	Value	Language
dc.contributor.author	Girard-Madoux, Mathilde J. H.	-
dc.contributor.author	Ober-Blöbaum, Juliane L.	-
dc.contributor.author	Costes, Léa M. M.	-
dc.contributor.author	Kel, Junda M.	-
dc.contributor.author	Lindenbergh-Kortleve, Dicky J.	-
dc.contributor.author	Brouwers-Haspels, Inge	-
dc.contributor.author	Heikema, Astrid P.	-
dc.contributor.author	Samsom, Janneke N.	-
dc.contributor.author	Clausen, Björn	-
dc.date.accessioned	2022-10-10T08:02:27Z	-
dc.date.available	2022-10-10T08:02:27Z	-
dc.date.issued	2016	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7936	-
dc.description.abstract	Although IL-10 promotes a regulatory phenotype of CD11c(+) dendritic cells and macrophages in vitro, the role of IL-10 signaling in CD11c(+) cells to maintain intestinal tolerance in vivo remains elusive. To this aim, we generated mice with a CD11c-specific deletion of the IL-10 receptor alpha (Cd11c(cre)Il10ra(fl/fl)). In contrast to the colon, the small intestine of Cd11c(cre)Il10ra(fl/fl) mice exhibited spontaneous crypt hyperplasia, increased numbers of intraepithelial lymphocytes and lamina propria T cells, associated with elevated levels of T cell-derived IFN gamma and IL-17A. Whereas naive mucosal T-cell priming was not affected and oral tolerance to ovalbumin was intact, augmented T-cell function in the lamina propria was associated with elevated numbers of locally dividing T cells, expression of T-cell attracting chemokines and reduced T-cell apoptosis. Upon stimulation, intestinal IL-10Ra deficient CD11c(+) cells exhibited increased activation associated with enhanced IL-6 and TNFa production. Following colonization with Helicobacter hepaticus Cd11c(cre)Il10ra(fl/fl) mice developed severe large intestinal inflammation characterized by infiltrating T cells and increased levels of Il17a, Ifng, and Il12p40. Altogether these findings demonstrate a critical role of IL-10 signaling in CD11c(+) cells to control small intestinal immune homeostasis by limiting reactivation of local memory T cells and to protect against Helicobacter hepaticus-induced colitis.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/3.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	IL-10 control of CD11c+ myeloid cells is essential to maintain immune homeostasis in the small and large intestine	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7921	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	OncoTarget	de
jgu.journal.volume	7	de
jgu.journal.issue	22	de
jgu.pages.start	32015	de
jgu.pages.end	32030	de
jgu.publisher.year	2016	-
jgu.publisher.name	Impact Journals LLC	de
jgu.publisher.place	S.l.	de
jgu.publisher.uri	http://dx.doi.org/10.18632/oncotarget.8337	de
jgu.publisher.issn	1949-2553	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2018-08-23T08:23:45Z	-
opus.subject.dfgcode	00-000	-
opus.organisation.string	FB 04: Medizin: Institut für Molekulare Medizin	de_DE
opus.identifier.opusid	56330	-
opus.institute.number	0458	-
opus.metadataonly	false	-
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Clausen, Björn	-
jgu.publisher.doi	10.18632/oncotarget.8337	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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