Gutenberg Open Science: Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7905

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DC Field	Value	Language
dc.contributor.author	Frühbeis, Carsten	-
dc.contributor.author	Fröhlich, Dominik	-
dc.contributor.author	Kuo, Wen Ping	-
dc.contributor.author	Amphornrath, Jesa	-
dc.contributor.author	Thilemann, Sebastian	-
dc.contributor.author	Saab, Aiman S.	-
dc.contributor.author	Kirchhoff, Frank	-
dc.contributor.author	Möbius, Wiebke	-
dc.contributor.author	Goebbels, Sandra	-
dc.contributor.author	Nave, Klaus-Armin	-
dc.contributor.author	Schneider, Anja	-
dc.contributor.author	Simons, Mikael	-
dc.contributor.author	Klugmann, Matthias	-
dc.contributor.author	Trotter, Jacqueline	-
dc.contributor.author	Albers, Eva-Maria	-
dc.date.accessioned	2022-10-07T09:28:04Z	-
dc.date.available	2022-10-07T09:28:04Z	-
dc.date.issued	2013	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7920	-
dc.description.abstract	Reciprocal interactions between neurons and oligodendrocytes are not only crucial for myelination, but also for long-term survival of axons. Degeneration of axons occurs in several human myelin diseases, however the molecular mechanisms of axon-glia communication maintaining axon integrity are poorly understood. Here, we describe the signal-mediated transfer of exosomes from oligodendrocytes to neurons. These endosome-derived vesicles are secreted by oligodendrocytes and carry specific protein and RNA cargo. We show that activity-dependent release of the neurotransmitter glutamate triggers oligodendroglial exosome secretion mediated by Ca2+ entry through oligodendroglial NMDA and AMPA receptors. In turn, neurons internalize the released exosomes by endocytosis. Injection of oligodendroglia-derived exosomes into the mouse brain results in functional retrieval of exosome cargo in neurons. Supply of cultured neurons with oligodendroglial exosomes improves neuronal viability under conditions of cell stress. These findings indicate that oligodendroglial exosomes participate in a novel mode of bidirectional neuron-glia communication contributing to neuronal integrity.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/3.0/	*
dc.subject.ddc	050 Zeitschriften	de_DE
dc.subject.ddc	050 General serials and their indexes	en_GB
dc.title	Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7905	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 10 Biologie	de
jgu.organisation.number	7970	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	PLoS biology	de
jgu.journal.volume	11	de
jgu.journal.issue	7	de
jgu.pages.start	1	de
jgu.pages.end	19	de
jgu.pages.alternative	e1001604	de
jgu.publisher.year	2013	-
jgu.publisher.name	PLoS	de
jgu.publisher.place	Lawrence, KS	de
jgu.publisher.uri	http://dx.doi.org/10.1371/journal.pbio.1001604	de
jgu.publisher.issn	1545-7885	de
jgu.publisher.issn	1544-9173	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	050	de
opus.date.modified	2018-07-30T10:16:59Z	-
opus.subject.dfgcode	04-206	-
opus.organisation.string	FB 10: Biologie: Abteilung Molekulare Zellbiologie / Biologie für Mediziner	de_DE
opus.identifier.opusid	23320	-
opus.institute.number	1004	-
opus.metadataonly	false	-
opus.type.contenttype	Forschungsbericht	de_DE
opus.type.contenttype	Research Report	en_EN
opus.affiliated	Trotter, Jacqueline	-
opus.affiliated	Albers, Eva-Maria	-
jgu.publisher.doi	10.1371/journal.pbio.1001604	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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