Authors:	Frühbeis, Carsten Fröhlich, Dominik Kuo, Wen Ping Amphornrath, Jesa Thilemann, Sebastian Saab, Aiman S. Kirchhoff, Frank Möbius, Wiebke Goebbels, Sandra Nave, Klaus-Armin Schneider, Anja Simons, Mikael Klugmann, Matthias Trotter, Jacqueline Albers, Eva-Maria
Title:	Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication
Online publication date:	7-Oct-2022
Year of first publication:	2013
Language:	english
Abstract:	Reciprocal interactions between neurons and oligodendrocytes are not only crucial for myelination, but also for long-term survival of axons. Degeneration of axons occurs in several human myelin diseases, however the molecular mechanisms of axon-glia communication maintaining axon integrity are poorly understood. Here, we describe the signal-mediated transfer of exosomes from oligodendrocytes to neurons. These endosome-derived vesicles are secreted by oligodendrocytes and carry specific protein and RNA cargo. We show that activity-dependent release of the neurotransmitter glutamate triggers oligodendroglial exosome secretion mediated by Ca2+ entry through oligodendroglial NMDA and AMPA receptors. In turn, neurons internalize the released exosomes by endocytosis. Injection of oligodendroglia-derived exosomes into the mouse brain results in functional retrieval of exosome cargo in neurons. Supply of cultured neurons with oligodendroglial exosomes improves neuronal viability under conditions of cell stress. These findings indicate that oligodendroglial exosomes participate in a novel mode of bidirectional neuron-glia communication contributing to neuronal integrity.
DDC:	050 Zeitschriften 050 General serials and their indexes
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 10 Biologie
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7905
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/3.0/
Journal:	PLoS biology 11 7
Pages or article number:	1 19 e1001604
Publisher:	PLoS
Publisher place:	Lawrence, KS
Issue date:	2013
ISSN:	1545-7885 1544-9173
Publisher URL:	http://dx.doi.org/10.1371/journal.pbio.1001604
Publisher DOI:	10.1371/journal.pbio.1001604
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)