Autoren:	Frühbeis, Carsten Fröhlich, Dominik Kuo, Wen Ping Amphornrath, Jesa Thilemann, Sebastian Saab, Aiman S. Kirchhoff, Frank Möbius, Wiebke Goebbels, Sandra Nave, Klaus-Armin Schneider, Anja Simons, Mikael Klugmann, Matthias Trotter, Jacqueline Albers, Eva-Maria
Titel:	Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication
Online-Publikationsdatum:	7-Okt-2022
Erscheinungsdatum:	2013
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	Reciprocal interactions between neurons and oligodendrocytes are not only crucial for myelination, but also for long-term survival of axons. Degeneration of axons occurs in several human myelin diseases, however the molecular mechanisms of axon-glia communication maintaining axon integrity are poorly understood. Here, we describe the signal-mediated transfer of exosomes from oligodendrocytes to neurons. These endosome-derived vesicles are secreted by oligodendrocytes and carry specific protein and RNA cargo. We show that activity-dependent release of the neurotransmitter glutamate triggers oligodendroglial exosome secretion mediated by Ca2+ entry through oligodendroglial NMDA and AMPA receptors. In turn, neurons internalize the released exosomes by endocytosis. Injection of oligodendroglia-derived exosomes into the mouse brain results in functional retrieval of exosome cargo in neurons. Supply of cultured neurons with oligodendroglial exosomes improves neuronal viability under conditions of cell stress. These findings indicate that oligodendroglial exosomes participate in a novel mode of bidirectional neuron-glia communication contributing to neuronal integrity.
DDC-Sachgruppe:	050 Zeitschriften 050 General serials and their indexes
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 10 Biologie
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7905
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/3.0/
Zeitschrift:	PLoS biology 11 7
Seitenzahl oder Artikelnummer:	1 19 e1001604
Verlag:	PLoS
Verlagsort:	Lawrence, KS
Erscheinungsdatum:	2013
ISSN:	1545-7885 1544-9173
URL der Originalveröffentlichung:	http://dx.doi.org/10.1371/journal.pbio.1001604
DOI der Originalveröffentlichung:	10.1371/journal.pbio.1001604
Enthalten in den Sammlungen:	DFG-OA-Publizieren (2012 - 2017)