Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7902
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Keller, Stefanie | - |
dc.contributor.author | Schmidt, Mirko HH | - |
dc.date.accessioned | 2022-10-07T09:18:43Z | - |
dc.date.available | 2022-10-07T09:18:43Z | - |
dc.date.issued | 2017 | |
dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/7917 | - |
dc.description.abstract | Epidermal growth factor receptor (EGFR) and the mutant EGFRvIII are major focal points in current concepts of targeted cancer therapy for glioblastoma multiforme (gbm), the most malignant primary brain tumor. the receptors participate in the key processes of tumor cell invasion and tumor-related angiogenesis and their upregulation correlates with the poor prognosis of glioma patients. glioma cell invasion and increased angiogenesis share mechanisms of the degradation of the extracellular matrix (ecm) through upregulation of ecm-degrading proteases as well as the activation of aberrant signaling pathways. this review describes the role of egfr and egfrviii in those mechanisms which might offer new combined therapeutic approaches targeting egfr or egfrviii together with drug treatments against proteases of the ecm or downstream signaling to increase the inhibitory effects of mono-therapies. | en_GB |
dc.description.sponsorship | DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin | de |
dc.language.iso | eng | de |
dc.rights | CC BY | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.ddc | 610 Medizin | de_DE |
dc.subject.ddc | 610 Medical sciences | en_GB |
dc.title | EGFR and EGFRvIII promote angiogenesis and cell invasion in glioblastoma : combination therapies for an effective treatment | en_GB |
dc.type | Zeitschriftenaufsatz | de |
dc.identifier.doi | http://doi.org/10.25358/openscience-7902 | - |
jgu.type.dinitype | article | en_GB |
jgu.type.version | Published version | de |
jgu.type.resource | Text | de |
jgu.organisation.department | FB 04 Medizin | de |
jgu.organisation.number | 2700 | - |
jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
jgu.rights.accessrights | openAccess | - |
jgu.journal.title | International journal of molecular sciences | de |
jgu.journal.volume | 18 | de |
jgu.journal.issue | 6 | de |
jgu.pages.alternative | Art. 1295 | de |
jgu.publisher.year | 2017 | - |
jgu.publisher.name | Molecular Diversity Preservation International | de |
jgu.publisher.place | Basel | de |
jgu.publisher.uri | http://dx.doi.org/10.3390/ijms18061295 | de |
jgu.publisher.issn | 1422-0067 | de |
jgu.publisher.issn | 1661-6596 | de |
jgu.organisation.place | Mainz | - |
jgu.subject.ddccode | 610 | de |
opus.date.modified | 2018-03-23T11:17:38Z | |
opus.subject.dfgcode | 00-000 | |
opus.organisation.string | FB 04: Medizin: Institut für Mikroskopische Anatomie und Neurobiologie | de_DE |
opus.identifier.opusid | 57999 | |
opus.institute.number | 0459 | |
opus.metadataonly | false | |
opus.type.contenttype | Keine | de_DE |
opus.type.contenttype | None | en_EN |
opus.affiliated | Schmidt, Mirko HH | |
jgu.publisher.doi | 10.3390/ijms18061295 | de |
jgu.organisation.ror | https://ror.org/023b0x485 | - |
Appears in collections: | DFG-OA-Publizieren (2012 - 2017) |
Files in This Item:
File | Description | Size | Format | ||
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egfr_and_egfrviii_promote_ang-20220924204028118.pdf | 1.25 MB | Adobe PDF | View/Open |