Gutenberg Open Science: The correlation between chronic periodontitis and oral cancer

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7894

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DC Field	Value	Language
dc.contributor.author	Krüger, Maximilian	-
dc.contributor.author	Hansen, Torsten	-
dc.contributor.author	Kasaj, Adrian	-
dc.contributor.author	Moergel, Maximilian	-
dc.date.accessioned	2022-10-06T10:22:56Z	-
dc.date.available	2022-10-06T10:22:56Z	-
dc.date.issued	2013	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7909	-
dc.description.abstract	Infections are increasingly considered as potential trigger for carcinogenesis apart from risk factors like alcohol and tobacco. The discussion about human papilloma virus (HPV) in oral squamous cell carcinoma (OSCC) points at a general role of infection for the development of oral carcinomas. Furthermore, first studies describe a correlation between chronic periodontitis and OSCC, thus, characterizing chronic inflammation as being a possible trigger for OSCC. In front of this background, we present four well-documented clinical cases. All patients showed a significant anatomical relation between OSCC and clinical signs of chronic periodontitis. The interindividual differences of the clinical findings lead to different theoretical concepts: two with coincidental appearance of OSCC and chronic periodontitis and two with possible de novo development of OSCC triggered by chronic inflammation. We conclude that the activation of different inflammatory cascades by chronic periodontitis negatively affects mucosa and bone. Furthermore, the inflammatory response has the potential to activate carcinogenesis. Apart from a mere coincidental occurrence, two out of four patients give first clinical hints for a model wherein chronic periodontitis represents a potential risk factor for the development of OSCC.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/3.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	The correlation between chronic periodontitis and oral cancer	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7894	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Case reports in dentistry	de
jgu.journal.volume	2013	de
jgu.pages.alternative	Art. 262410	de
jgu.publisher.year	2013	-
jgu.publisher.name	Hindawi	de
jgu.publisher.place	New York, NY	de
jgu.publisher.uri	http://dx.doi.org/10.1155/2013/262410	de
jgu.publisher.issn	2090-6447	de
jgu.publisher.issn	2090-6455	de
jgu.organisation.place	Mainz	-
jgu.identifier.pmid	23936684	-
jgu.subject.ddccode	610	de
opus.date.modified	2018-07-31T10:03:36Z	-
opus.subject.dfgcode	00-000	-
opus.organisation.string	FB 04: Medizin: Klinik und Polikliniken für Zahn-, Mund- und Kieferkrankheiten	de_DE
opus.organisation.string	FB 04: Medizin: Poliklinik für Zahnerhaltungskunde	de_DE
opus.identifier.opusid	25529	-
opus.importsource	pubmed	-
opus.institute.number	0448	-
opus.institute.number	0452	-
opus.metadataonly	false	-
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Kasaj, Adrian	-
opus.affiliated	Moergel, Maximilian	-
jgu.publisher.doi	10.1155/2013/262410	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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