Gutenberg Open Science: Components of the plasminogen activation system promote engraftment of porous polyethylene biomaterial via common and distinct effects

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7849

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DC Field	Value	Language
dc.contributor.author	Reichel, Christoph A.	-
dc.contributor.author	Hessenauer, Maximilian E. T.	-
dc.contributor.author	Pflieger, Kerstin	-
dc.contributor.author	Rehberg, Markus	-
dc.contributor.author	Kanse, Sandip M.	-
dc.contributor.author	Zahler, Stefan	-
dc.contributor.author	Krombach, Fritz	-
dc.contributor.author	Berghaus, Alexander	-
dc.contributor.author	Strieth, Sebastian	-
dc.date.accessioned	2022-10-05T09:10:59Z	-
dc.date.available	2022-10-05T09:10:59Z	-
dc.date.issued	2015
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7864	-
dc.description.abstract	Rapid fibrovascularization is a prerequisite for successful biomaterial engraftment. In addition to their well-known roles in fibrinolysis, urokinase-type plasminogen activator (uPA) and tissue plasminogen activator (tPA) or their inhibitor plasminogen activator inhibitor-1 (PAI-1) have recently been implicated as individual mediators in non-fibrinolytic processes, including cell adhesion, migration, and proliferation. Since these events are critical for fibrovascularization of biomaterial, we hypothesized that the components of the plasminogen activation system contribute to biomaterial engraftment. Employing in vivo and ex vivo microscopy techniques, vessel and collagen network formation within porous polyethylene (PPE) implants engrafted into dorsal skinfold chambers were found to be significantly impaired in uPA-, tPA-, or PAI-1-deficient mice. Consequently, the force required for mechanical disintegration of the implants out of the host tissue was significantly lower in the mutant mice than in wild-type controls. Conversely, surface coating with recombinant uPA, tPA, non-catalytic uPA, or PAI-1, but not with non-catalytic tPA, accelerated implant vascularization in wild-type mice. Thus, uPA, tPA, and PAI-1 contribute to the fibrovascularization of PPE implants through common and distinct effects. As clinical perspective, surface coating with recombinant uPA, tPA, or PAI-1 might provide a novel strategy for accelerating the vascularization of this biomaterial.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Components of the plasminogen activation system promote engraftment of porous polyethylene biomaterial via common and distinct effects	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7849	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	PLoS one	de
jgu.journal.volume	10	de
jgu.journal.issue	2	de
jgu.pages.alternative	e0116883	de
jgu.publisher.year	2015	-
jgu.publisher.name	PLoS	de
jgu.publisher.place	Lawrence, Kan.	de
jgu.publisher.uri	http://dx.doi.org/10.1371/journal.pone.0116883	de
jgu.publisher.issn	1932-6203	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2018-09-05T09:12:30Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 04: Medizin: Hals-, Nasen- und Ohren-Klinik und Poliklinik	de_DE
opus.identifier.opusid	51968
opus.institute.number	0447
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Strieth, Sebastian
jgu.publisher.doi	10.1371/journal.pone.0116883	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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