Gutenberg Open Science: Low tidal volume pressure support versus controlled ventilation in early experimental sepsis in pigs

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7838

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DC Field	Value	Language
dc.contributor.author	Ziebart, Alexander	-
dc.contributor.author	Hartmann, Erik	-
dc.contributor.author	Thomas, Rainer	-
dc.contributor.author	Liu, Tanghua	-
dc.contributor.author	Duenges, Bastian	-
dc.contributor.author	Schad, Arno	-
dc.contributor.author	Bodenstein, Marc	-
dc.contributor.author	Thal, Serge	-
dc.contributor.author	David, Matthias	-
dc.date.accessioned	2022-10-05T08:31:04Z	-
dc.date.available	2022-10-05T08:31:04Z	-
dc.date.issued	2014
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7853	-
dc.description.abstract	BACKGROUND In moderate acute respiratory distress syndrome (ARDS) several studies support the usage of assisted spontaneous breathing modes. Only limited data, however, focus on the application in systemic sepsis and developing lung injury. The present study examines the effects of immediate initiation of pressure support ventilation (PSV) in a model of sepsis-induced ARDS. METHODS 18 anesthetized pigs received a two-staged continuous lipopolysaccharide infusion to induce lung injury. The animals were randomly assigned to PSV or volume controlled (VCV) lung protective ventilation (tidal volume each 6 ml kg-1, n = 2x9) over six hours. Gas exchange parameters, hemodynamics, systemic inflammation, and ventilation distribution by multiple inert gas elimination and electrical impedance tomography were assessed. The post mortem analysis included histopathological scoring, wet to dry ratio, and alveolar protein content. RESULTS Within six hours both groups developed a mild to moderate ARDS with comparable systemic inflammatory response and without signs of improving gas exchange parameters during PSV. The PSV group showed signs of more homogenous ventilation distribution by electrical impedance tomography, but only slightly less hyperinflated lung compartments by multiple inert gas elimination. Post mortem and histopathological assessment yielded no significant intergroup differences. CONCLUSIONS In a porcine model of sepsis-induced mild ARDS immediate PSV was not superior to VCV. This contrasts with several experimental studies from non-septic mild to moderate ARDS. The present study therefore assumes that not only severity, but also etiology of lung injury considerably influences the response to early initiation of PSV.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Low tidal volume pressure support versus controlled ventilation in early experimental sepsis in pigs	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7838	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Respiratory research	de
jgu.journal.volume	15	de
jgu.pages.alternative	Art. 101	de
jgu.publisher.year	2014	-
jgu.publisher.name	Biomed Central	de
jgu.publisher.place	London	de
jgu.publisher.uri	http://dx.doi.org/10.1186/s12931-014-0101-6	de
jgu.publisher.issn	1465-993X	de
jgu.publisher.issn	1465-9921	de
jgu.identifier.wos	000342371200001
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2018-08-09T08:20:57Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 04: Medizin: Klinik für Anästhesiologie	de_DE
opus.organisation.string	FB 04: Medizin: Institut für Pathologie	de_DE
opus.identifier.opusid	50542
opus.importsource	WoS
opus.institute.number	0418
opus.institute.number	0423
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Ziebart, Alexander
opus.affiliated	Hartmann, Erik
opus.affiliated	Thomas, Rainer
opus.affiliated	Schad, Arno
opus.affiliated	Bodenstein, Marc
opus.affiliated	Thal, Serge
jgu.publisher.doi	10.1186/s12931-014-0101-6	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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