Gutenberg Open Science: First insight into the proteome landscape of the porcine short posterior ciliary arteries : key signalling pathways maintaining physiologic functions

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7804

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DC Field	Value	Language
dc.contributor.author	Manicam, Caroline	-
dc.contributor.author	Perumal, Natarajan	-
dc.contributor.author	Pfeiffer, Norbert	-
dc.contributor.author	Grus, Franz-Hermann	-
dc.contributor.author	Gericke, Adrian	-
dc.date.accessioned	2022-10-04T09:17:33Z	-
dc.date.available	2022-10-04T09:17:33Z	-
dc.date.issued	2016
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7819	-
dc.description.abstract	Short posterior ciliary arteries (sPCA) provide the major blood supply to the optic nerve head. Emerging evidence has linked structural and functional anomalies of sPCA to the pathogenesis of several ocular disorders that cause varying degrees of visual loss, particularly anterior ischaemic optic neuropathy and glaucoma. Although the functional relevance of this vascular bed is well-recognized, the proteome of sPCA remains uncharacterized. Since the porcine ocular system closely resembles that of the human’s and is increasingly employed in translational ophthalmic research, this study characterized the proteome of porcine sPCA employing the mass spectrometry-based proteomics strategy. A total of 1742 proteins and 10527 peptides were identified in the porcine sPCA. The major biological processes involved in the maintenance of physiological functions of the sPCA included redox and metabolic processes, and cytoskeleton organization. These proteins were further clustered into diverse signalling pathways that regulate vasoactivity of sPCA, namely the tight junction, α- and β-adrenoceptor, 14-3-3, nitric oxide synthase and endothelin-1 -mediated signalling pathways. This study provides the first insight into the complex mechanisms dictating the vast protein repertoire in normal vascular physiology of the porcine sPCA. It is envisioned that our findings will serve as important benchmarks for future studies of sPCA.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	First insight into the proteome landscape of the porcine short posterior ciliary arteries : key signalling pathways maintaining physiologic functions	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7804	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Scientific reports	de
jgu.journal.volume	6	de
jgu.pages.alternative	Art. 8298	de
jgu.publisher.year	2016	-
jgu.publisher.name	Nature Publishing Group	de
jgu.publisher.place	London	de
jgu.publisher.uri	http://dx.doi.org/10.1038/srep38298	de
jgu.publisher.issn	2045-2322	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2018-08-23T08:55:28Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 04: Medizin: Augenklinik und Poliklinik	de_DE
opus.identifier.opusid	56428
opus.institute.number	0446
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Pfeiffer, Norbert
opus.affiliated	Grus, Franz-Hermann
opus.affiliated	Gericke, Adrian
jgu.publisher.doi	10.1038/srep38298	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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