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Autoren: Arnold, Natalie
Gori, Tommaso
Schnabel, Renate B.
Schulz, Andreas
Prochaska, Jürgen H.
Zeller, Tanja
Binder, Harald
Pfeiffer, Norbert
Beutel, Manfred E.
Espinola-Klein, Christine
Lackner, Karl J.
Blankenberg, Stefan
Münzel, Thomas
Wild, Philipp
Titel: Relation between arterial stiffness and markers of inflammation and hemostasis : data from the population-based Gutenberg Health Study
Online-Publikationsdatum: 4-Okt-2022
Erscheinungsdatum: 2017
Sprache des Dokuments: Englisch
Zusammenfassung/Abstract: The relation between inflammation, hemostasis and arterial stiffness is of pathophysiological relevance for the development of cardiovascular disease (CVD). Data investigating this interplay using stiffness index (SI) by digital photoplethysmography are not available yet. Therefore, sex-specific relation between SI and inflammatory and hemostatic biomarkers was investigated within 13,724 subjects from the population-based Gutenberg Health Study. C-reactive protein (CRP), white blood cell count (WBCC), neopterin, interleukin-18, interleukin-1 receptor antagonist (IL-1RA), fibrinogen and hematocrit were measured. Multivariable linear regression analysis with adjustment for cardiovascular risk factors, medication, and hormonal status (in females) revealed an independent association between SI and WBCC, IL-1RA and hematocrit in both sexes, and with fibrinogen in women. There was a joint effect of increasing tertiles of SI and biomarker concentrations for future CVD risk prediction. Subjects with both SI and biomarker concentration above the median had the worst overall survival and with both below the median the best survival during a follow-up period of 6.2 ± 1.7 years, except for hematocrit. The results support the relation between inflammation, hemostasis and arterial stiffness measured by digital photoplethysmography. Markers of inflammation and hemostasis modulate the ability of SI to identify subjects at risk for future CVD or higher mortality.
DDC-Sachgruppe: 610 Medizin
610 Medical sciences
Veröffentlichende Institution: Johannes Gutenberg-Universität Mainz
Organisationseinheit: FB 04 Medizin
Veröffentlichungsort: Mainz
ROR: https://ror.org/023b0x485
DOI: http://doi.org/10.25358/openscience-7795
Version: Published version
Publikationstyp: Zeitschriftenaufsatz
Nutzungsrechte: CC BY
Informationen zu den Nutzungsrechten: https://creativecommons.org/licenses/by/4.0/
Zeitschrift: Scientific reports
7
Seitenzahl oder Artikelnummer: Art. 6346
Verlag: Macmillan Publishers Limited, part of Springer Nature
Verlagsort: London
Erscheinungsdatum: 2017
ISSN: 2045-2322
URL der Originalveröffentlichung: http://dx.doi.org/10.1038/s41598-017-06175-2
DOI der Originalveröffentlichung: 10.1038/s41598-017-06175-2
Enthalten in den Sammlungen:DFG-OA-Publizieren (2012 - 2017)

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