Gutenberg Open Science: Physiological properties of supragranular cortical inhibitory interneurons expressing retrograde persistent firing

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7751

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DC Field	Value	Language
dc.contributor.author	Imbrosci, Barbara	-
dc.contributor.author	Neitz, Angela	-
dc.contributor.author	Mittmann, Thomas	-
dc.date.accessioned	2022-09-14T08:03:44Z	-
dc.date.available	2022-09-14T08:03:44Z	-
dc.date.issued	2015	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7766	-
dc.description.abstract	Neurons are polarized functional units. The somatodendritic compartment receives and integrates synaptic inputs while the axon relays relevant synaptic information in form of action potentials (APs) across long distance. Despite this well accepted notion, recent research has shown that, under certain circumstances, the axon can also generate APs independent of synaptic inputs at axonal sites distal from the soma. These ectopic APs travel both toward synaptic terminals and antidromically toward the soma. This unusual form of neuronal communication seems to preferentially occur in cortical inhibitory interneurons following a period of intense neuronal activity and might have profound implications for neuronal information processing. Here we show that trains of ectopically generated APs can be induced in a large portion of neocortical layer 2/3 GABAergic interneurons following a somatic depolarization inducing hundreds of APs. Sparsely occurring ectopic spikes were also observed in a large portion of layer 1 interneurons even in absence of prior somatic depolarization. Remarkably, we found that interneurons which produce ectopic APs display specific membrane and morphological properties significantly different from the remaining GABAergic cells and may therefore represent a functionally unique interneuronal subpopulation.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/3.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Physiological properties of supragranular cortical inhibitory interneurons expressing retrograde persistent firing	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7751	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Neural plasticity	de
jgu.journal.volume	2015	de
jgu.pages.alternative	Art. 608141	de
jgu.publisher.year	2015	-
jgu.publisher.name	Hindawi	de
jgu.publisher.place	New York, NY	de
jgu.publisher.uri	http://dx.doi.org/10.1155/2015/608141	de
jgu.publisher.issn	1687-5443	de
jgu.publisher.issn	2090-5904	de
jgu.organisation.place	Mainz	-
jgu.identifier.pmid	25763283	-
jgu.subject.ddccode	610	de
opus.date.modified	2018-09-05T09:13:25Z	-
opus.subject.dfgcode	00-000	-
opus.organisation.string	FB 04: Medizin: Institut für Physiologie und Pathophysiologie	de_DE
opus.identifier.opusid	51971	-
opus.importsource	pubmed	-
opus.institute.number	0403	-
opus.metadataonly	false	-
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Imbrosci, Barbara	-
opus.affiliated	Mittmann, Thomas	-
jgu.publisher.doi	10.1155/2015/608141	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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