Gutenberg Open Science: The protein structure context of polyQ regions

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7743

Full metadata record

DC Field	Value	Language
dc.contributor.author	Totzeck, Franziska	-
dc.contributor.author	Andrade, Miguel	-
dc.contributor.author	Mier, Pablo	-
dc.date.accessioned	2022-09-14T07:40:05Z	-
dc.date.available	2022-09-14T07:40:05Z	-
dc.date.issued	2017
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7758	-
dc.description.abstract	Proteins containing glutamine repeats (polyQ) are known to be structurally unstable. Abnormal expansion of polyQ in some proteins exceeding a certain threshold leads to neurodegenerative disease, a symptom of which are protein aggregates. This has led to extensive research of the structure of polyQ stretches. However, the accumulation of contradictory results suggests that protein context might be of importance. Here we aimed to evaluate the structural context of polyQ regions in proteins by analysing the secondary structure of polyQ proteins and their homologs. The results revealed that the secondary structure in polyQ vicinity is predominantly random coil or helix. Importantly, the regions surrounding the polyQ are often not solved in 3D structures. In the few cases where the point of insertion of the polyQ was mapped to a full protein, we observed that these are always located in the surface of the protein. The findings support the hypothesis that polyQ might serve to extend coiled coils at their C-terminus in highly disordered regions involved in protein-protein interactions.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	570 Biowissenschaften	de_DE
dc.subject.ddc	570 Life sciences	en_GB
dc.title	The protein structure context of polyQ regions	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7743	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 10 Biologie	de
jgu.organisation.number	7970	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	PLoS one	de
jgu.journal.volume	12	de
jgu.journal.issue	1	de
jgu.pages.alternative	e0170801	de
jgu.publisher.year	2017	-
jgu.publisher.name	PLoS	de
jgu.publisher.place	Lawrence, Kan.	de
jgu.publisher.uri	http://dx.doi.org/10.1371/journal.pone.0170801	de
jgu.publisher.issn	1932-6203	de
jgu.notes.public	Andrade, Miguel veröffentlicht unter: Andrade-Navarro, Miguel A.	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	570	de
opus.date.modified	2018-05-18T09:23:09Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 10: Biologie: Institut für Organismische und Molekulare Evolutionsbiologie	de_DE
opus.identifier.opusid	56533
opus.institute.number	1011
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Andrade, Miguel
opus.affiliated	Mier, Pablo
jgu.publisher.doi	10.1371/journal.pone.0170801	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

Files in This Item:

	File	Description	Size	Format
	the_protein_structure_context-20220913185143669.pdf		1.18 MB	Adobe PDF	View/Open

Show simple item record