Gutenberg Open Science: Ophthalmic complications of Lemierre syndrome

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7716

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DC Field	Value	Language
dc.contributor.author	Kreuzpointner, Robert	-
dc.contributor.author	Valerio, Luca	-
dc.contributor.author	Corsi, Gabriele	-
dc.contributor.author	Zane, Federica	-
dc.contributor.author	Sacco, Clara	-
dc.contributor.author	Holm, Karin	-
dc.contributor.author	Righini, Christian	-
dc.contributor.author	Pecci, Alessandro	-
dc.contributor.author	Zweifel, Sandrine	-
dc.contributor.author	Barco, Stefano	-
dc.date.accessioned	2022-09-12T09:28:57Z	-
dc.date.available	2022-09-12T09:28:57Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7731	-
dc.description.abstract	Purpose Lemierre syndrome is a life-threatening condition characterized by head/neck bacterial infection, local suppurative thrombophlebitis and septic embolic complications in a range of sites of distant organs. No prior study focused on the course and characteristics of ophthalmic complications of Lemierre syndrome. Methods We analysed data of 27 patients with ophthalmic complications from a large cohort of 712 cases with Lemierre syndrome reported globally between 2000 and 2017. We focused on initial manifestations, early (in-hospital) course and long-term ophthalmic deficits at the time of hospital discharge or during postdischarge follow-up. The study protocol was registered in the International Prospective Register of Systematic Reviews PROSPERO (CRD42016052572). Results Nine (33%) patients were women; the median age was 20 (Q1–Q3: 15–33) years. Fusobacterium spp. was involved in 56% of cases. The most prevalent initial manifestations were decreased vision (35%) and periocular oedema (38%), followed by impaired eye movements/nerve palsy (28%) and proptosis (28%). Venous involvement, notably cerebral vein thrombosis (70%) and ophthalmic vein thrombosis (55%), explained the symptomatology in most cases. Septic embolism (7%), orbital abscesses (2%) and carotid stenosis (14%) were also present. Ophthalmic sequelae were reported in 9 (33%) patients, often consisting of blindness or reduced visual acuity, and nerve paralysis/paresis. Conclusion Ophthalmic complications represent a severe manifestation of Lemierre syndrome, often reflecting an underlying cerebral vein thrombosis. Visual acuity loss and long-term severe complications are frequent. We call for an interdisciplinary approach to the management of patients with Lemierre syndrome and the routine involvement of ophthalmologists.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY-NC-ND	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Ophthalmic complications of Lemierre syndrome	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7716	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Acta ophthalmologica	de
jgu.journal.volume	100	de
jgu.journal.issue	1	de
jgu.pages.start	e314	de
jgu.pages.end	e320	de
jgu.publisher.year	2022	-
jgu.publisher.name	Blackwell	de
jgu.publisher.place	Oxford	de
jgu.publisher.issn	1755-3768	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1111/aos.14871	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	JGU-Publikationen

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