Gutenberg Open Science: Role of AMPA receptor desensitization in short term depression : lessons from retinogeniculate synapses

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7707

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DC Field	Value	Language
dc.contributor.author	Engelhardt, Jakob von	-
dc.date.accessioned	2022-09-12T08:48:32Z	-
dc.date.available	2022-09-12T08:48:32Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7722	-
dc.description.abstract	Repetitive synapse activity induces various forms of short-term plasticity. The role of presynaptic mechanisms such as residual Ca2+ and vesicle depletion in short-term facilitation and short-term depression is well established. On the other hand, the contribution of postsynaptic mechanisms such as receptor desensitization and saturation to short-term plasticity is less well known and often ignored. In this review, I will describe short-term plasticity in retinogeniculate synapses of relay neurons of the dorsal lateral geniculate nucleus (dLGN) to exemplify the synaptic properties that facilitate the contribution of AMPA receptor desensitization to short-term plasticity. These include high vesicle release probability, glutamate spillover and, importantly, slow recovery from desensitization of AMPA receptors. The latter is strongly regulated by the interaction of AMPA receptors with auxiliary proteins such as CKAMP44. Finally, I discuss the relevance of short-term plasticity in retinogeniculate synapses for the processing of visual information by LGN relay neurons.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Role of AMPA receptor desensitization in short term depression : lessons from retinogeniculate synapses	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7707	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	The journal of physiology	de
jgu.journal.volume	600	de
jgu.journal.issue	2	de
jgu.pages.start	201	de
jgu.pages.end	215	de
jgu.publisher.year	2022	-
jgu.publisher.name	Wiley-Blackwell	de
jgu.publisher.place	Hoboken, NJ	de
jgu.publisher.issn	1469-7793	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1113/JP280878	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	JGU-Publikationen

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