Gutenberg Open Science: L-Citrulline ameliorates pathophysiology in a rat model of superimposed preeclampsia

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7672

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DC Field	Value	Language
dc.contributor.author	Man, Andy W. C.	-
dc.contributor.author	Zhou, Yawen	-
dc.contributor.author	Lam, Uyen D. P.	-
dc.contributor.author	Reifenberg, Gisela	-
dc.contributor.author	Werner, Anke	-
dc.contributor.author	Habermeier, Alice	-
dc.contributor.author	Closs, Ellen I.	-
dc.contributor.author	Daiber, Andreas	-
dc.contributor.author	Münzel, Thomas	-
dc.contributor.author	Xia, Ning	-
dc.contributor.author	Li, Huige	-
dc.date.accessioned	2022-09-05T08:54:18Z	-
dc.date.available	2022-09-05T08:54:18Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7687	-
dc.description.abstract	Background and Purpose Preeclampsia, characterized by hypertension, proteinuria and restriction of fetal growth, is one of the leading causes of maternal and perinatal mortality. So far, there is no effective pharmacological therapy for preeclampsia. The present study was conducted to investigate the effects of supplementation with l-citrulline in Dahl salt-sensitive rats, a model of superimposed preeclampsia. Experimental Approach Parental Dahl salt-sensitive rats were treated with l-citrulline (2.5 g·L−1 in drinking water) from the day of mating to the end of lactation period. Blood pressure was monitored throughout pregnancy and markers of preeclampsia were assessed. Endothelial function of the pregnant Dahl salt-sensitive rats was assessed by wire myograph. Key Results In Dahl salt-sensitive rats, l-citrulline supplementation significantly reduced maternal blood pressure, proteinuria and levels of circulating soluble fms-like tyrosine kinase 1. l-Citrulline improved maternal endothelial function by augmenting the production of nitric oxide in the aorta and improving endothelium-derived hyperpolarizing factor-mediated vasorelaxation in resistance arteries. l-Citrulline supplementation improved placental insufficiency and fetal growth, which were associated with an enhancement of angiogenesis and reduction of fibrosis and senescence in the placentas. In addition, l-citrulline down-regulated genes involved in the TLR4 and NF-κB signalling pathways. Conclusion and Implications This study shows that l-citrulline supplementation reduced gestational hypertension and improved placentation and fetal growth in a rat model of superimposed preeclampsia. l-Citrulline supplementation may provide an effective and safe therapeutic strategy for preeclampsia that benefits both the mother and the fetus.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY-NC	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	L-Citrulline ameliorates pathophysiology in a rat model of superimposed preeclampsia	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7672	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	British journal of pharmacology	de
jgu.journal.volume	179	de
jgu.journal.issue	12	de
jgu.pages.start	3007	de
jgu.pages.end	3023	de
jgu.publisher.year	2022	-
jgu.publisher.name	Wiley	de
jgu.publisher.place	Malden, MA	de
jgu.publisher.issn	1476-5381	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1111/bph.15783	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	JGU-Publikationen

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