Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7578Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Teister, Julia | - |
| dc.contributor.author | Anders, F. | - |
| dc.contributor.author | Beck, Sabine | - |
| dc.contributor.author | Funke, S. | - |
| dc.contributor.author | Pein, H. von | - |
| dc.contributor.author | Prokosch-Willing, Verena | - |
| dc.contributor.author | Pfeiffer, Norbert | - |
| dc.contributor.author | Grus, Franz-Hermann | - |
| dc.date.accessioned | 2022-08-19T10:03:26Z | - |
| dc.date.available | 2022-08-19T10:03:26Z | - |
| dc.date.issued | 2017 | |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/7592 | - |
| dc.description.abstract | Although elevated intraocular pressure (IOP) remains the major risk factor in glaucoma, neurodegenerative processes continue despite effective IOP lowering. Altered α-synuclein antibody (Abs) levels have been reported to play a crucial role. This study aimed at identifying whether α-synuclein Abs are capable to decelerate neuronal decay while providing insights into proteomic changes. Four groups of Sprague Dawley rats received episcleral vein occlusion: (1) CTRL, no intravitreal injection, n = 6, (2) CTRL IgG, intravitreal injection of unspecific IgG, n = 5, (3) Buffer, intravitreal injection of buffer, n = 6, (4), α-synuclein Ab, intravitreal injection of α-synuclein Ab, n = 5. IOP and retinal nerve fiber layer thickness (RNFLT) were monitored and immunohistochemistry, microarray and proteomic analysis were performed. RNFLT was reduced in CTRL, CTRL IgG and Buffer group (all p < 0.01) and α-synuclein Ab group (p = 0.17). Axon and RGC density showed an increased neurodegeneration in CTRL, CTRL IgG and Buffer group (all p < 0.01) and increased neuronal survival in α-synuclein Ab group (p = 0.38 and 0.06, respectively) compared with fellow eyes. Proteomic analysis revealed alterations of cofilin 1 and superoxide dismutase 1 expression. This data indicate that α-synuclein Ab might indirectly modulate the actin cytoskeleton organization and negatively regulate apoptotic processes via cofilin 1 and superoxide dismutase 1. | en_GB |
| dc.description.sponsorship | DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin | de |
| dc.language.iso | eng | de |
| dc.rights | CC BY | * |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | Decelerated neurodegeneration after intravitreal injection of α-synuclein antibodies in a glaucoma animal model | en_GB |
| dc.type | Zeitschriftenaufsatz | de |
| dc.identifier.doi | http://doi.org/10.25358/openscience-7578 | - |
| jgu.type.dinitype | article | en_GB |
| jgu.type.version | Published version | de |
| jgu.type.resource | Text | de |
| jgu.organisation.department | FB 04 Medizin | de |
| jgu.organisation.number | 2700 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | Scientific reports | de |
| jgu.journal.volume | 7 | de |
| jgu.journal.issue | 1 | de |
| jgu.pages.alternative | Art. 6260 | de |
| jgu.publisher.year | 2017 | - |
| jgu.publisher.name | Macmillan Publishers Limited, part of Springer Nature | de |
| jgu.publisher.place | London | de |
| jgu.publisher.uri | http://dx.doi.org/10.1038/s41598-017-06702-1 | de |
| jgu.publisher.issn | 2045-2322 | de |
| jgu.notes.public | Prokosch-Willing, Verena veröffentlicht unter: Prokosch, Verena | de |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 610 | de |
| opus.date.modified | 2018-04-05T08:06:40Z | |
| opus.subject.dfgcode | 00-000 | |
| opus.organisation.string | FB 04: Medizin: Augenklinik und Poliklinik | de_DE |
| opus.identifier.opusid | 57967 | |
| opus.institute.number | 0446 | |
| opus.metadataonly | false | |
| opus.type.contenttype | Keine | de_DE |
| opus.type.contenttype | None | en_EN |
| opus.affiliated | Prokosch-Willing, Verena | |
| opus.affiliated | Pfeiffer, Norbert | |
| opus.affiliated | Grus, Franz-Hermann | |
| jgu.publisher.doi | 10.1038/s41598-017-06702-1 | de |
| jgu.organisation.ror | https://ror.org/023b0x485 | - |
| Appears in collections: | DFG-OA-Publizieren (2012 - 2017) | |
Files in This Item:
| File | Description | Size | Format | ||
|---|---|---|---|---|---|
 | decelerated_neurodegeneration-20220817163444959.pdf | 6.54 MB | Adobe PDF | View/Open |