Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7444
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dc.contributor.authorLaspas, Panagiotis-
dc.contributor.authorCulmann, P. D.-
dc.contributor.authorGrus, Franz-Hermann-
dc.contributor.authorProkosch-Willing, Verena-
dc.contributor.authorPoplawksi, A.-
dc.contributor.authorPfeiffer, Norbert-
dc.contributor.authorHoffmann, Esther M.-
dc.date.accessioned2022-07-15T10:08:12Z-
dc.date.available2022-07-15T10:08:12Z-
dc.date.issued2017-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/7458-
dc.description.abstractPurpose To compare two surgical approaches for treating encapsulated blebs after trabeculectomy with mitomycin C, in terms of the development of intraocular pressure and progression of glaucoma in a long-term follow up: 1. bleb needling alone vs. 2. a combined approach of needling with additional transconjunctival scleral flap sutures, to prevent early ocular hypotony. Methods Forty-six patients with failing blebs after trabeculectomy with mitomycin C were enrolled in this study. Patients received either needling revision alone (group 1; n = 23) or a combined needling with additional transconjuctival flap sutures, if intraoperatively the intraocular pressure was estimated to be low (group 2; n = 23). Intraocular pressure (IOP), visual acuity, visual fields, and optic nerve head configuration by means of Heidelberg Retina Tomograph (HRT®) were analysed over time. Results from both groups were compared using Mann-Whitney U-test for single timepoints. Results IOP did not differ significantly between the two groups during follow-up at three months (P = 0.13), six months (P = 0.12), one year (P = 0.92) and two years (P = 0.57) after surgery. Furthermore, there was no significant difference in the course of glaucoma concerning the optic nerve anatomy between the two groups (Rim Area Change in the Moorfields Regression Analysis of HRT®) till two years after surgery (P = 0.289). No functional impairment in visual acuity and visual fields was found in the groups of the study. Conclusions Single needling procedure is a standard successful method for restoring the function of encapsulated blebs. Postoperative hypotony represents a possible hazard, which can be minimized by additional transconjunctival flap sutures. Long-term results suggest that this modification is equally effective in lowering the IOP and preventing the progression of glaucoma as the standard needling procedure. To our knowledge this is the first study to investigate the long-term effect of tranconjunctival sutures for the prevention of hypotony.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizinde
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleRevision of encapsulated blebs after trabeculectomy : long-term comparison of standard bleb needling and modified needling procedure combined with transconjunctival scleral flap suturesen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-7444-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titlePLOS ONEde
jgu.journal.volume12de
jgu.journal.issue5de
jgu.pages.alternativee0178099de
jgu.publisher.year2017-
jgu.publisher.namePLOSde
jgu.publisher.placeSan Francisco, California, USde
jgu.publisher.urihttp://dx.doi.org/10.1371/journal.pone.0178099de
jgu.publisher.issn1932-6203de
jgu.organisation.placeMainz-
jgu.subject.ddccode610de
opus.date.modified2018-04-04T08:09:05Z-
opus.subject.dfgcode00-000-
opus.organisation.stringFB 04: Medizin: Augenklinik und Poliklinikde_DE
opus.identifier.opusid57977-
opus.institute.number0446-
opus.metadataonlyfalse-
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_EN
opus.affiliatedLaspas, Panagiotis-
opus.affiliatedGrus, Franz-Hermann-
opus.affiliatedProkosch-Willing, Verena-
opus.affiliatedPfeiffer, Norbert-
opus.affiliatedHoffmann, Esther-
jgu.publisher.doi10.1371/journal.pone.0178099de
jgu.organisation.rorhttps://ror.org/023b0x485-
Appears in collections:DFG-OA-Publizieren (2012 - 2017)

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