Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7391
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dc.contributor.authorBicker, Anne-
dc.contributor.authorBrahmer, Alexandra-
dc.contributor.authorMeller, Sebastian-
dc.contributor.authorKristiansen, Glen-
dc.contributor.authorGorr, Thomas A.-
dc.contributor.authorHankeln, Thomas-
dc.date.accessioned2022-07-13T09:20:58Z-
dc.date.available2022-07-13T09:20:58Z-
dc.date.issued2015
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/7405-
dc.description.abstractMyoglobin (MB) is not only strongly expressed in myocytes, but also at much lower levels in different cancer entities. 40% of breast tumors are MB-positive, with the globin being co-expressed with markers of tumor hypoxia in a proportion of cases. In breast cancer, MB expression is associated with a positive hormone receptor status and patient prognosis. In prostate cancer, another hormone-dependent cancer type, 53% of tumors were recently shown to express MB. Especially in more aggressive prostate cancer specimen MB expression also correlates with increased patient survival rates. Both findings might be due to tumor-suppressing properties of MB in cancer cells. In contrast to muscle, MB transcription in breast and prostate cancer mainly depends on a novel, alternative promoter site. We show here that its associated transcripts can be upregulated by hypoxia and downregulated by estrogens and androgens in MCF7 breast and LNCaP prostate cancer cells, respectively. Bioinformatic data mining of epigenetic histone marks and experimental verification reveal a hitherto uncharacterized transcriptional network that drives the regulation of the MB gene in cancer cells. We identified candidate hormone-receptor binding elements that may interact with the cancer-associated MB promoter to decrease its activity in breast and prostate cancer cells. Additionally, a regulatory element, 250 kb downstream of the promoter, acts as a hypoxia-inducible site within the transcriptional machinery. Understanding the distinct regulation of MB in tumors will improve unraveling the respiratory protein’s function in the cancer context and may provide new starting points for developing therapeutic strategies.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizinde
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc570 Biowissenschaftende_DE
dc.subject.ddc570 Life sciencesen_GB
dc.titleThe distinct gene regulatory network of myoglobin in prostate and breast canceren_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-7391-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 02 Sozialwiss., Medien u. Sportde
jgu.organisation.departmentFB 10 Biologiede
jgu.organisation.number7910-
jgu.organisation.number7970-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titlePLoS onede
jgu.journal.volume10de
jgu.journal.issue11de
jgu.pages.alternativee0142662de
jgu.publisher.year2015-
jgu.publisher.namePLoSde
jgu.publisher.placeLawrence, Kan.de
jgu.publisher.urihttp://dx.doi.org/10.1371/journal.pone.0142662de
jgu.publisher.issn1932-6203de
jgu.organisation.placeMainz-
jgu.subject.ddccode570de
opus.date.modified2017-05-12T09:16:26Z
opus.subject.dfgcode00-000
opus.organisation.stringFB 02: Sozialwissenschaften, Medien und Sport: Institut für Sportwissenschaftde_DE
opus.organisation.stringFB 10: Biologie: Institut für Molekulargenetik, Gentechnologische Sicherheitsforschung und Beratungde_DE
opus.identifier.opusid52625
opus.institute.number0208
opus.institute.number1006
opus.metadataonlyfalse
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_EN
opus.affiliatedBicker, Anne
opus.affiliatedBrahmer, Alexandra
opus.affiliatedHankeln, Thomas
jgu.publisher.doi10.1371/journal.pone.0142662de
jgu.organisation.rorhttps://ror.org/023b0x485-
Appears in collections:DFG-OA-Publizieren (2012 - 2017)

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