Gutenberg Open Science: Acute effects of strength exercises and effects of regular strength training on cell free DNA concentrations in blood plasma

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7383

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DC Field	Value	Language
dc.contributor.author	Tug, Suzan	-
dc.contributor.author	Tross, Anna-Katharina	-
dc.contributor.author	Hegen, Patrick	-
dc.contributor.author	Neuberger, Elmo	-
dc.contributor.author	Helmig, Susanne	-
dc.contributor.author	Schöllhorn, Wolfgang	-
dc.contributor.author	Simon, Perikles	-
dc.date.accessioned	2022-07-12T09:15:12Z	-
dc.date.available	2022-07-12T09:15:12Z	-
dc.date.issued	2017
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7397	-
dc.description.abstract	Creatine kinase (CK) is a marker for muscle cell damage with limited potential as marker for training load in strength training. Recent exercise studies identified cell free DNA (cfDNA) as a marker for aseptic inflammation and cell damage. Here we overserved in a pilot study the acute effects during strength exercise and chronic effects of regular strength training on cfDNA concentrations over a period of four weeks in three training groups applying conservation training (CT) at 60% of the 1 repetition maximum, high intensity-low repetition training (HT) at 90% of the 1 repetition maximum and differential training (DT) at 60% of the 1 repetition maximum. EDTA-plasma samples were collected before every training session, and on the first and last training day repeatedly after every set of exercises. CfDNA increased significantly by 1.62-fold (mean (±SD) before first exercise: 8.31 (2.84) ng/ml, after last exercise 13.48 (4.12) ng/ml) across all groups within a single training session (p<0.001). The increase was 1.77-fold higher (mean (±SD) before first exercise: 12.23 (6.29) ng/ml, after last exercise 17.73 (11.24) ng/ml) in HT compared to CT (mean (±SD) before first exercise: 6.79 (1.28) ng/ml, after last exercise 10.05 (2.89) ng/ml) (p = 0.01). DNA size analysis suggested predominant release of short, mononucleosomal DNA-fragments in the acute exercise setting, while we detected an increase of mostly longer, polynucleosomal cfDNA-fragments at rest before the training session only at day two with a subsequent return to baseline (p<0.001). In contrast, training procedures did not cause any alterations in CK. Our results suggest that during strength exercise short-fragmented cfDNA is released, reflecting a fast, aseptic inflammatory response, while elevation of longer fragments at baseline on day two seemed to reflect mild cellular damage due to a novel training regime. We critically discuss the implications of our findings for future evaluations of cfDNA as a marker for training load in strength training.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	796 Sport	de_DE
dc.subject.ddc	796 Athletic and outdoor sports and games	en_GB
dc.title	Acute effects of strength exercises and effects of regular strength training on cell free DNA concentrations in blood plasma	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7383	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 02 Sozialwiss., Medien u. Sport	de
jgu.organisation.number	7910	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	PLoS one	de
jgu.journal.volume	12	de
jgu.journal.issue	9	de
jgu.pages.alternative	e0184668	de
jgu.publisher.year	2017	-
jgu.publisher.name	PLoS	de
jgu.publisher.place	Lawrence, Kan.	de
jgu.publisher.uri	http://dx.doi.org/10.1371/journal.pone.0184668	de
jgu.publisher.issn	1932-6203	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	796	de
opus.date.modified	2017-11-15T09:22:48Z
opus.subject.dfgcode	04-205
opus.organisation.string	FB 02: Sozialwissenschaften, Medien und Sport: Institut für Sportwissenschaft	de_DE
opus.identifier.opusid	57485
opus.institute.number	0208
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Tug, Suzan
opus.affiliated	Hegen, Patrick
opus.affiliated	Neuberger, Elmo
opus.affiliated	Helmig, Susanne
opus.affiliated	Schöllhorn, Wolfgang
opus.affiliated	Simon, Perikles
jgu.publisher.doi	10.1371/journal.pone.0184668	de
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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