Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7363Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ghanaati, Shahram | - |
| dc.contributor.author | Udeabor, Samuel E. | - |
| dc.contributor.author | Barbeck, Mike | - |
| dc.contributor.author | Willershausen, Ines | - |
| dc.contributor.author | Kuenzel, Oliver | - |
| dc.contributor.author | Sader, Robert A. | - |
| dc.contributor.author | Kirkpatrick, Charles James | - |
| dc.date.accessioned | 2022-07-12T07:27:28Z | - |
| dc.date.available | 2022-07-12T07:27:28Z | - |
| dc.date.issued | 2013 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/7377 | - |
| dc.description.abstract | BACKGROUND: Osteoinductive bone substitutes are defined by their ability to induce new bone formation even at heterotopic implantation sites. The present study was designed to analyze the potential osteoinductivity of two different bone substitute materials in caprine muscle tissue. MATERIALS AND METHODS: One gram each of either a porous beta-tricalcium phosphate (beta-TCP) or an hydroxyapatite/silicon dioxide (HA/SiO2)-based nanocrystalline bone substitute material was implanted in several muscle pouches of goats. The biomaterials were explanted at 29, 91 and 181 days after implantation. Conventional histology and special histochemical stains were performed to detect osteoblast precursor cells as well as mineralized and unmineralized bone matrix. RESULTS: Both materials underwent cellular degradation in which tartrate-resistant acid phosphatase (TRAP)-positive osteoclast-like cells and TRAP-negative multinucleated giant cells were involved. The ss-TCP was completely resorbed within the observation period, whereas some granules of the HA-groups were still detectable after 180 days. Neither osteoblasts, osteoblast precursor cells nor extracellular bone matrix were found within the implantation bed of any of the analyzed biomaterials at any of the observed time points. CONCLUSIONS: This study showed that ss-TCP underwent a faster degradation than the HA-based material. The lack of osteoinductivity for both materials might be due to their granular shape, as osteoinductivity in goat muscle has been mainly attributed to cylindrical or disc-shaped bone substitute materials. This hypothesis however requires further investigation to systematically analyze various materials with comparable characteristics in the same experimental setting. | en_GB |
| dc.description.sponsorship | DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin | de |
| dc.language.iso | eng | de |
| dc.rights | CC BY | * |
| dc.rights.uri | https://creativecommons.org/licenses/by/2.0/ | * |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | Implantation of silicon dioxide-based nanocrystalline hydroxyapatite and pure phase beta-tricalciumphosphate bone substitute granules in caprine muscle tissue does not induce new bone formation | en_GB |
| dc.type | Zeitschriftenaufsatz | de |
| dc.identifier.doi | http://doi.org/10.25358/openscience-7363 | - |
| jgu.type.dinitype | article | en_GB |
| jgu.type.version | Published version | de |
| jgu.type.resource | Text | de |
| jgu.organisation.department | FB 04 Medizin | de |
| jgu.organisation.number | 2700 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | Head & face medicine | de |
| jgu.journal.volume | 9 | de |
| jgu.pages.alternative | Art. 1 | de |
| jgu.publisher.year | 2013 | - |
| jgu.publisher.name | BioMed Central | de |
| jgu.publisher.place | London | de |
| jgu.publisher.uri | http://dx.doi.org/10.1186/1746-160X-9-1 | de |
| jgu.publisher.issn | 1746-160X | de |
| jgu.organisation.place | Mainz | - |
| jgu.identifier.pmid | 23286366 | - |
| jgu.subject.ddccode | 610 | de |
| opus.date.modified | 2018-07-30T10:02:36Z | - |
| opus.subject.dfgcode | 00-000 | - |
| opus.organisation.string | FB 04: Medizin: Institut für Pathologie | de_DE |
| opus.organisation.string | FB 04: Medizin: Poliklinik für Zahnerhaltungskunde | de_DE |
| opus.identifier.opusid | 22896 | - |
| opus.importsource | pubmed | - |
| opus.institute.number | 0423 | - |
| opus.institute.number | 0452 | - |
| opus.metadataonly | false | - |
| opus.type.contenttype | Keine | de_DE |
| opus.type.contenttype | None | en_EN |
| opus.affiliated | Willershausen, Ines | - |
| opus.affiliated | Kirkpatrick, Charles James | - |
| jgu.publisher.doi | 10.1186/1746-160X-9-1 | de |
| jgu.organisation.ror | https://ror.org/023b0x485 | |
| Appears in collections: | DFG-OA-Publizieren (2012 - 2017) | |
Files in This Item:
| File | Description | Size | Format | ||
|---|---|---|---|---|---|
 | implantation_of_silicon_dioxi-20220710214526662.pdf | 1.06 MB | Adobe PDF | View/Open |