Gutenberg Open Science: Spontaneous neuronal activity in developing neocortical networks : from single cells to large-scale cortical interactions

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7355

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DC Field	Value	Language
dc.contributor.author	Luhmann, Heiko	-
dc.contributor.author	Sinning, Anne	-
dc.contributor.author	Yang, Jenq-Wei	-
dc.contributor.author	Reyes-Puerta, Vicente	-
dc.contributor.author	Stüttgen, Maik C.	-
dc.contributor.author	Kirischuk, Sergei	-
dc.contributor.author	Kilb, Werner	-
dc.date.accessioned	2022-07-11T10:36:48Z	-
dc.date.available	2022-07-11T10:36:48Z	-
dc.date.issued	2016
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7369	-
dc.description.abstract	Neuronal activity has been shown to be essential for the proper formation of neuronal circuits, affecting developmental processes like neurogenesis, migration, programmed cell death, cellular differentiation, formation of local and long-range axonal connections, synaptic plasticity or myelination. Accordingly, neocortical areas reveal distinct spontaneous and sensory-driven neuronal activity patterns already at early phases of development. At embryonic stages, when immature neurons start to develop voltage-dependent channels, spontaneous activity is highly synchronized within small neuronal networks and governed by electrical synaptic transmission. Subsequently, spontaneous activity patterns become more complex, involve larger networks and propagate over several neocortical areas. The developmental shift from local to large-scale network activity is accompanied by a gradual shift from electrical to chemical synaptic transmission with an initial excitatory action of chloride-gated channels activated by GABA, glycine and taurine. Transient neuronal populations in the subplate support temporary circuits that play an important role in tuning early neocortical activity and the formation of mature neuronal networks. Thus, early spontaneous activity patterns control the formation of developing networks in sensory cortices, and disturbances of these activity patterns may lead to long-lasting neuronal deficits.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Spontaneous neuronal activity in developing neocortical networks : from single cells to large-scale cortical interactions	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7355	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Frontiers in neural circuits	de
jgu.journal.volume	10	de
jgu.pages.alternative	Art. 40	de
jgu.publisher.year	2016	-
jgu.publisher.name	Frontiers Research Foundation	de
jgu.publisher.place	Lausanne	de
jgu.publisher.uri	http://dx.doi.org/10.3389/fncir.2016.00040	de
jgu.publisher.issn	1662-5110	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2020-02-06T11:07:54Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 04: Medizin: Institut für Physiologie und Pathophysiologie	de_DE
opus.identifier.opusid	56375
opus.institute.number	0403
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Luhmann, Heiko
opus.affiliated	Reyes-Puerta, Vicente
opus.affiliated	Stüttgen, Maik C.
jgu.publisher.doi	10.3389/fncir.2016.00040	de
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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