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http://doi.org/10.25358/openscience-7157Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Hartmann, Erik | - |
| dc.contributor.author | Thomas, Rainer | - |
| dc.contributor.author | Liu, Tanghua | - |
| dc.contributor.author | Stefaniak, Joanna | - |
| dc.contributor.author | Ziebart, Alexander | - |
| dc.contributor.author | Duenges, Bastian | - |
| dc.contributor.author | Eckle, Daniel | - |
| dc.contributor.author | Markstaller, Klaus | - |
| dc.contributor.author | David, Matthias | - |
| dc.date.accessioned | 2022-06-15T08:49:18Z | - |
| dc.date.available | 2022-06-15T08:49:18Z | - |
| dc.date.issued | 2014 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/7171 | - |
| dc.description.abstract | BACKGROUND: Inhalation of TIP peptides that mimic the lectin-like domain of TNF-alpha is a novel approach to attenuate pulmonary oedema on the threshold to clinical application. A placebo-controlled porcine model of acute respiratory distress syndrome (ARDS) demonstrated a reduced thermodilution-derived extravascular lung water index (EVLWI) and improved gas exchange through TIP peptide inhalation within three hours. Based on these findings, the present study compares a single versus a repetitive inhalation of a TIP peptide (TIP-A) and two alternate peptide versions (TIP-A, TIP-B). METHODS: Following animal care committee approval ARDS was induced by bronchoalveolar lavage followed by injurious ventilation in 21 anaesthetized pigs. A randomised-blinded three-group setting compared the single-dosed peptide variants TIP-A and TIP-B as well as single versus repetitive inhalation of TIP-A (n = 7 per group). Over two three-hour intervals parameters of gas exchange, transpulmonary thermodilution, calculated alveolar fluid clearance, and ventilation/perfusion-distribution were assessed. Post-mortem measurements included pulmonary wet/dry ratio and haemorrhage/congestion scoring. RESULTS: The repetitive TIP-A inhalation led to a significantly lower wet/dry ratio than a single dose and a small but significantly lower EVLWI. However, EVLWI changes over time and the derived alveolar fluid clearance did not differ significantly. The comparison of TIP-A and B showed no relevant differences. Gas exchange and ventilation/perfusion-distribution significantly improved in all groups without intergroup differences. No differences were found in haemorrhage/congestion scoring. CONCLUSIONS: In comparison to a single application the repetitive inhalation of a TIP peptide in three-hour intervals may lead to a small additional reduction the lung water content. Two alternate TIP peptide versions showed interchangeable characteristics. | en_GB |
| dc.description.sponsorship | DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin | de |
| dc.language.iso | eng | de |
| dc.rights | CC BY | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/2.0/ | * |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | TIP peptide inhalation in experimental acute lung injury : effect of repetitive dosage and different synthetic variants | en_GB |
| dc.type | Zeitschriftenaufsatz | de |
| dc.identifier.doi | http://doi.org/10.25358/openscience-7157 | - |
| jgu.type.dinitype | article | en_GB |
| jgu.type.version | Published version | de |
| jgu.type.resource | Text | de |
| jgu.organisation.department | FB 04 Medizin | de |
| jgu.organisation.number | 2700 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | BMC anesthesiology | de |
| jgu.journal.volume | 14 | de |
| jgu.pages.alternative | Art. 42 | de |
| jgu.publisher.year | 2014 | - |
| jgu.publisher.name | BioMed central | de |
| jgu.publisher.place | S.l. | de |
| jgu.publisher.uri | http://dx.doi.org/10.1186/1471-2253-14-42 | de |
| jgu.publisher.issn | 1471-2253 | de |
| jgu.organisation.place | Mainz | - |
| jgu.identifier.pmid | 24904234 | - |
| jgu.subject.ddccode | 610 | de |
| opus.date.modified | 2018-08-08T09:02:12Z | - |
| opus.subject.dfgcode | 00-000 | - |
| opus.organisation.string | FB 04: Medizin: Klinik für Anästhesiologie | de_DE |
| opus.identifier.opusid | 27378 | - |
| opus.importsource | pubmed | - |
| opus.institute.number | 0418 | - |
| opus.metadataonly | false | - |
| opus.type.contenttype | Keine | de_DE |
| opus.type.contenttype | None | en_EN |
| opus.affiliated | Hartmann, Erik | - |
| opus.affiliated | Thomas, Rainer | - |
| opus.affiliated | Ziebart, Alexander | - |
| opus.affiliated | Eckle, Daniel | - |
| jgu.publisher.doi | 10.1186/1471-2253-14-42 | de |
| jgu.organisation.ror | https://ror.org/023b0x485 | |
| Appears in collections: | DFG-OA-Publizieren (2012 - 2017) | |
Files in This Item:
| File | Description | Size | Format | ||
|---|---|---|---|---|---|
 | tip_peptide_inhalation_in_exp-20220612164311752.pdf | 373.64 kB | Adobe PDF | View/Open |