Gutenberg Open Science: Mosaic subventricular origins of forebrain oligodendrogenesis

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7144

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DC Field	Value	Language
dc.contributor.author	Azim, Kasum	-
dc.contributor.author	Berninger, Benedikt	-
dc.contributor.author	Raineteau, Olivier	-
dc.date.accessioned	2022-06-14T08:06:55Z	-
dc.date.available	2022-06-14T08:06:55Z	-
dc.date.issued	2016
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7158	-
dc.description.abstract	In the perinatal as well as the adult CNS, the subventricular zone (SVZ) of the forebrain is the largest and most active source of neural stem cells (NSCs) that generates neurons and oligodendrocytes (OLs), the myelin forming cells of the CNS. Recent advances in the field are beginning to shed light regarding SVZ heterogeneity, with the existence of spatially segregated microdomains that are intrinsically biased to generate phenotypically distinct neuronal populations. Although most research has focused on this regionalization in the context of neurogenesis, newer findings underline that this also applies for the genesis of OLs under the control of specific patterning molecules. In this mini review, we discuss the origins as well as the mechanisms that induce and maintain SVZ regionalization. These come in the flavor of specific signaling ligands and subsequent initiation of transcriptional networks that provide a basis for subdividing the SVZ into distinct lineage-specific microdomains. We further emphasize canonical Wnts and FGF2 as essential signaling pathways for the regional genesis of OL progenitors from NSCs of the dorsal SVZ. This aspect of NSC biology, which has so far received little attention, may unveil new avenues for appropriately recruiting NSCs in demyelinating diseases.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Mosaic subventricular origins of forebrain oligodendrogenesis	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7144	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Frontiers in neuroscience	de
jgu.journal.volume	10	de
jgu.pages.alternative	Art. 107	de
jgu.publisher.year	2016	-
jgu.publisher.name	Frontiers Research Foundation	de
jgu.publisher.place	Lausanne	de
jgu.publisher.uri	http://dx.doi.org/10.3389/fnins.2016.00107	de
jgu.publisher.issn	1662-4548	de
jgu.publisher.issn	1662-453X	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2018-08-23T08:13:09Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 04: Medizin: Institut für Physiologische Chemie und Pathobiochemie	de_DE
opus.identifier.opusid	56307
opus.institute.number	0404
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Azim, Kasum
opus.affiliated	Berninger, Benedikt
jgu.publisher.doi	10.3389/fnins.2016.00107	de
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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