Gutenberg Open Science: Resveratrol and endothelial nitric oxide

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7141

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DC Field	Value	Language
dc.contributor.author	Xia, Ning	-
dc.contributor.author	Förstermann, Ulrich	-
dc.contributor.author	Li, Huige	-
dc.date.accessioned	2022-06-14T07:29:40Z	-
dc.date.available	2022-06-14T07:29:40Z	-
dc.date.issued	2014
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7155	-
dc.description.abstract	Nitric oxide (NO) derived from the endothelial NO synthase (eNOS) has antihypertensive, antithrombotic, anti-atherosclerotic and antiobesogenic properties. Resveratrol is a polyphenol phytoalexin with multiple cardiovascular and metabolic effects. Part of the beneficial effects of resveratrol are mediated by eNOS. Resveratrol stimulates NO production from eNOS by a number of mechanisms, including upregulation of eNOS expression, stimulation of eNOS enzymatic activity and reversal of eNOS uncoupling. In addition, by reducing oxidative stress, resveratrol prevents oxidative NO inactivation by superoxide thereby enhancing NO bioavailability. Molecular pathways underlying these effects of resveratrol involve SIRT1, AMPK, Nrf2 and estrogen receptors.	de_DE
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Resveratrol and endothelial nitric oxide	de_DE
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7141	-
jgu.type.contenttype	Review	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Molecules	de
jgu.journal.volume	19	de
jgu.journal.issue	10	de
jgu.pages.start	16102	de
jgu.pages.end	16121	de
jgu.publisher.year	2014	-
jgu.publisher.name	MDPI	de
jgu.publisher.place	Basel	de
jgu.publisher.uri	http://dx.doi.org/10.3390/molecules191016102	de
jgu.publisher.issn	1420-3049	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2018-08-09T08:24:09Z
opus.subject.dfgcode	04-205
opus.organisation.string	FB 04: Medizin: Institut für Pharmakologie	de_DE
opus.identifier.opusid	27362
opus.institute.number	0413
opus.metadataonly	false
opus.type.contenttype	Übersichtsartikel	de_DE
opus.type.contenttype	Review Article	en_EN
opus.affiliated	Xia, Ning
opus.affiliated	Förstermann, Ulrich
opus.affiliated	Li, Huige
jgu.publisher.doi	10.3390/molecules191016102	de
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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