Gutenberg Open Science: Parasite presence induces gene expression changes in an ant host related to immunity and longevity

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6476

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DC Field	Value	Language
dc.contributor.author	Stoldt, Marah	-
dc.contributor.author	Klein, Linda	-
dc.contributor.author	Beros, Sara	-
dc.contributor.author	Butter, Falk	-
dc.contributor.author	Jongepier, Evelien	-
dc.contributor.author	Feldmeyer, Barbara	-
dc.contributor.author	Foitzik, Susanne	-
dc.date.accessioned	2021-11-09T11:12:58Z	-
dc.date.available	2021-11-09T11:12:58Z	-
dc.date.issued	2021	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/6486	-
dc.description.abstract	Most species are either parasites or exploited by parasites, making parasite–host interactions a driver of evolution. Parasites with complex life cycles often evolve strategies to facilitate transmission to the definitive host by manipulating their intermediate host. Such manipulations could explain phenotypic changes in the ant Temnothorax nylanderi, the intermediate host of the cestode Anomotaenia brevis. In addition to behavioral and morphological alterations, infected workers exhibit prolonged lifespans, comparable to that of queens, which live up to two decades. We used transcriptomic data from cestodes and ants of different castes and infection status to investigate the molecular underpinnings of phenotypic alterations in infected workers and explored whether the extended lifespan of queens and infected workers has a common molecular basis. Infected workers and queens commonly upregulated only six genes, one of them with a known anti-aging function. Both groups overexpressed immune genes, although not the same ones. Our findings suggest that the lifespan extension of infected workers is not achieved via the expression of queen-specific genes. The analysis of the cestodes’ transcriptome revealed dominant expression of genes of the mitochondrial respiratory transport chain, which indicates an active metabolism and shedding light on the physiology of the parasite in its cysticercoid stage.	en_GB
dc.description.sponsorship	Open Access-Publizieren Universität Mainz / Universitätsmedizin Mainz	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	570 Biowissenschaften	de_DE
dc.subject.ddc	570 Life sciences	en_GB
dc.title	Parasite presence induces gene expression changes in an ant host related to immunity and longevity	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-6476	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 10 Biologie	de
jgu.organisation.number	7970	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Genes	de
jgu.journal.volume	12	de
jgu.journal.issue	1	de
jgu.pages.alternative	95	de
jgu.publisher.year	2021	-
jgu.publisher.name	MDPI	de
jgu.publisher.place	Basel	de
jgu.publisher.uri	https://doi.org/10.3390/genes12010095	de
jgu.publisher.issn	2073-4425	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	570	de
jgu.publisher.doi	10.3390/genes12010095
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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