Gutenberg Open Science: Epigenetics in Health and Disease: Focus on epigenetic mechanisms as systems of change and adaptability

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6473

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DC Field	Value	Language
dc.contributor.author	Butto, Tamer	-
dc.date.accessioned	2021-11-17T09:52:57Z	-
dc.date.available	2021-11-17T09:52:57Z	-
dc.date.issued	2021	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/6483	-
dc.description.abstract	Epigenetics can be described as the field that studies the distinct molecular mechanisms that modulate gene expression without entailing actual changes in the genetic sequence. The regulation of gene expression is a fundamental process in cellular and molecular biology, which ultimately promotes cellular adaptation in response to internal and external environmental stimuli. Epigenetic mechanisms such as DNA methylation, histone post translational modification (PTM), and non-coding RNA are the most broadly studied epigenetic mechanisms shown to play a vital role in the regular maintenance of distinct cellular populations as well as in the pathology of a variety of health-associated maladies. The current thesis presents a collection of studies addressing the distinctive roles of epigenetic mechanisms as systems of change and adaptability and their association with different healthy/diseased phenotypes. Such studies will focus on research topics involved in 1) Epigenetic treatment of genomic imprinting disorder, 2) transcriptional and epigenetic alterations associated with resilient behavior to chronic stress, 3) host-gut microbiota communication network associated with the stress-response system, and 4) transcriptional alterations associated with mTOR inhibition in adult neurons. In addition, several studies will highlight the progression of various methodologies used to monitor the diverse epigenetic alterations and their influence on gene expression changes. Each study provides a unique prospect emphasizing the role of the epigenetic mechanism in the referred health-associated condition as well as its broad function as an evolutionary tool of change and adaptability. Lastly, this thesis will present a novel outlook and concepts aiming to properly define and sub-classify the distinct epigenetic mechanisms based on their capacity of alteration and their necessity in various cellular populations. Such novel views could provide a stimulating re-evaluation of the distinct epigenetic mechanisms, which will encourage further examination of the basic models of epigenetics and will herewith contribute to the field’s further progression.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	000 Allgemeines	de_DE
dc.subject.ddc	000 Generalities	en_GB
dc.subject.ddc	500 Naturwissenschaften	de_DE
dc.subject.ddc	500 Natural sciences and mathematics	en_GB
dc.subject.ddc	570 Biowissenschaften	de_DE
dc.subject.ddc	570 Life sciences	en_GB
dc.title	Epigenetics in Health and Disease: Focus on epigenetic mechanisms as systems of change and adaptability	en_GB
dc.type	Dissertation	de
dc.identifier.urn	urn:nbn:de:hebis:77-openscience-0670f757-6c15-4dcc-94f6-ca30a86cc9972	-
dc.identifier.doi	http://doi.org/10.25358/openscience-6473	-
jgu.type.dinitype	doctoralThesis	en_GB
jgu.type.version	Original work	de
jgu.type.resource	Text	de
jgu.date.accepted	2021-10-15	-
jgu.description.extent	208 Seiten, Diagramme	de
jgu.organisation.department	FB 10 Biologie	de
jgu.organisation.number	7970	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	000	de
jgu.subject.ddccode	500	de
jgu.subject.ddccode	570	de
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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	butto_tamer-epigenetics_in-20211109093542658.pdf	PhD Dissertation - Tamer Butto	13.62 MB	Adobe PDF	View/Open

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