Gutenberg Open Science: Chitosan-based, biocompatible, solution processable films for in vivo localization of neural interface devices

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6401

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DC Field	Value	Language
dc.contributor.author	Rauhala, Onni J.	-
dc.contributor.author	Dominguez, Soledad	-
dc.contributor.author	Spyropoulos, George D.	-
dc.contributor.author	Ferrero, Jose Javier	-
dc.contributor.author	Boyers, Talia R.	-
dc.contributor.author	Jastrzebska-Perfect, Patricia	-
dc.contributor.author	Cea, Claudia	-
dc.contributor.author	Khodagholy, Dion	-
dc.contributor.author	Gelinas, Jennifer N.	-
dc.date.accessioned	2021-10-25T08:04:51Z	-
dc.date.available	2021-10-25T08:04:51Z	-
dc.date.issued	2020	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/6411	-
dc.description.abstract	Chitosan (CS) is a biocompatible, inexpensive organic polymer that is increasingly used in neural tissue applications. However, its intrinsic fluorescence has not yet been leveraged to facilitate localization of neural interface devices, a key procedure to ensure accurate analysis of neurophysiological signals. A process is developed to enable control of mechanical and chemical properties of CS-based composites, generating freestanding films that are stable in aqueous environments and exhibit concentration-dependent fluorescence intensity. The shape and location of CS-coated probes are reliably visualized in vitro and in vivo using fluorescence microscopy. Furthermore, CS neural probe marking is fully compatible with classical immunohistochemical and histological techniques, enabling localization of high spatiotemporal resolution surface electrocorticography arrays in adult rats and mouse pups. CS composites have the potential to simplify and streamline experimental procedures required to efficiently acquire, localize, and interpret neurophysiological data.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY-NC	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject.ddc	570 Biowissenschaften	de_DE
dc.subject.ddc	570 Life sciences	en_GB
dc.subject.ddc	600 Technik	de_DE
dc.subject.ddc	600 Technology (Applied sciences)	en_GB
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.subject.ddc	620 Ingenieurwissenschaften und Maschinenbau	de_DE
dc.subject.ddc	620 Engineering and allied operations	en_GB
dc.subject.ddc	621.3 Elektrotechnik	de_DE
dc.subject.ddc	621.3 Electric engineering	en_GB
dc.title	Chitosan-based, biocompatible, solution processable films for in vivo localization of neural interface devices	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-6401	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Advanced materials technologies	de
jgu.journal.volume	5	de
jgu.journal.issue	3	de
jgu.pages.alternative	1900663	de
jgu.publisher.year	2020	-
jgu.publisher.name	Wiley	de
jgu.publisher.place	Weinheim	de
jgu.publisher.uri	https://doi.org/10.1002/admt.201900663	de
jgu.publisher.issn	2365-709X	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	570	de
jgu.subject.ddccode	600	de
jgu.subject.ddccode	610	de
jgu.subject.ddccode	620	de
jgu.subject.ddccode	621.3	de
jgu.publisher.doi	10.1002/admt.201900663
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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