Gutenberg Open Science: Cell fate regulation upon DNA damage : p53 Serine 46 kinases pave the cell death road

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6277

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DC Field	Value	Language
dc.contributor.author	Liebl, Magdalena C.	-
dc.contributor.author	Hofmann, Thomas G.	-
dc.date.accessioned	2021-08-13T09:32:03Z	-
dc.date.available	2021-08-13T09:32:03Z	-
dc.date.issued	2019	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/6287	-
dc.description.abstract	Mild and massive DNA damage are differentially integrated into the cellular signaling networks and, in consequence, provoke different cell fate decisions. After mild damage, the tumor suppressor p53 directs the cellular response to cell cycle arrest, DNA repair, and cell survival, whereas upon severe damage, p53 drives the cell death response. One posttranslational modification of p53, phosphorylation at Serine 46, selectively occurs after severe DNA damage and is envisioned as a marker of the cell death response. However, the molecular mechanism of action of the p53 Ser46 phospho-isomer, the molecular timing of this phosphorylation event, and its activating effects on apoptosis and ferroptosis still await exploration. In this essay, the current body of evidence on the molecular function of this deadly p53 mark, its evolutionary conservation, and the regulation of the key players of this response, the p53 Serine 46 kinases, are reviewed and dissected.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Cell fate regulation upon DNA damage : p53 Serine 46 kinases pave the cell death road	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-6277	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Bioessays	de
jgu.journal.volume	41	de
jgu.journal.issue	12	de
jgu.pages.alternative	1900127	de
jgu.publisher.year	2019	-
jgu.publisher.name	Wiley-Liss	de
jgu.publisher.place	New York, NY	de
jgu.publisher.uri	https://doi.org/10.1002/bies.201900127	de
jgu.publisher.issn	1521-1878	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1002/bies.201900127
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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