Gutenberg Open Science: Functions of histone modifications and histone modifiers in Schwann cells

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6240

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DC Field	Value	Language
dc.contributor.author	Duman, Mert	-
dc.contributor.author	Martinez-Moreno, Margot	-
dc.contributor.author	Jacob, Claire	-
dc.contributor.author	Tapinos, Nikos	-
dc.date.accessioned	2021-08-06T07:55:17Z	-
dc.date.available	2021-08-06T07:55:17Z	-
dc.date.issued	2020	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/6250	-
dc.description.abstract	Schwann cells (SCs) are the main glial cells present in the peripheral nervous system (PNS). Their primary functions are to insulate peripheral axons to protect them from the environment and to enable fast conduction of electric signals along big caliber axons by enwrapping them in a thick myelin sheath rich in lipids. In addition, SCs have the peculiar ability to foster axonal regrowth after a lesion by demyelinating and converting into repair cells that secrete neurotrophic factors and guide axons back to their former target to finally remyelinate regenerated axons. The different steps of SC development and their role in the maintenance of PNS integrity and regeneration after lesion are controlled by various factors among which transcription factors and chromatin-remodeling enzymes hold major functions. In this review, we discussed how histone modifications and histone-modifying enzymes control SC development, maintenance of PNS integrity and response to injury. The functions of histone modifiers as part of chromatin-remodeling complexes are discussed in another review published in the same issue of Glia.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	570 Biowissenschaften	de_DE
dc.subject.ddc	570 Life sciences	en_GB
dc.title	Functions of histone modifications and histone modifiers in Schwann cells	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-6240	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 10 Biologie	de
jgu.organisation.number	7970	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Glia	de
jgu.journal.volume	68	de
jgu.journal.issue	8	de
jgu.pages.start	1584	de
jgu.pages.end	1595	de
jgu.publisher.year	2020	-
jgu.publisher.name	Wiley-Liss	de
jgu.publisher.place	Bognor Regis u.a.	de
jgu.publisher.uri	https://doi.org/10.1002/glia.23795	de
jgu.publisher.issn	1098-1136	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	570	de
jgu.publisher.doi	10.1002/glia.23795
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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