Gutenberg Open Science: Modulation of information processing by AMPA receptor auxiliary subunits

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6168

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DC Field	Value	Language
dc.contributor.author	Jacobi, Eric	-
dc.contributor.author	Engelhardt, Jakob von	-
dc.date.accessioned	2021-07-05T08:55:41Z	-
dc.date.available	2021-07-05T08:55:41Z	-
dc.date.issued	2021	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/6177	-
dc.description.abstract	AMPA-type glutamate receptors (AMPARs) are key molecules of neuronal communication in our brain. The discovery of AMPAR auxiliary subunits, such as proteins of the TARP, CKAMP and CNIH families, fundamentally changed our understanding of how AMPAR function is regulated. Auxiliary subunits control almost all aspects of AMPAR function in the brain. They influence AMPAR assembly, composition, structure, trafficking, subcellular localization and gating. This influence has important implications for synapse function. In the present review, we first discuss how auxiliary subunits affect the strength of synapses by modulating number and localization of AMPARs in synapses as well as their glutamate affinity, conductance and peak open probability. Next we explain how the presence of auxiliary subunits alters temporal precision and integrative properties of synapses by influencing gating kinetics of the receptors. Auxiliary subunits of the TARP and CKAMP family modulate synaptic short-term plasticity by increasing anchoring of AMPARs in synapses and by altering their desensitization kinetics. We then describe how auxiliary subunits of the TARP, CKAMP and CNIH families are involved in Hebbian and homeostatic plasticity, which can be explained by their influence on surface trafficking and synaptic targeting. In conclusion, the series of studies covered in this review show that auxiliary subunits play a pivotal role in controlling information processing in the brain by modulating synaptic computation.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Modulation of information processing by AMPA receptor auxiliary subunits	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-6168	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	The journal of physiology	de
jgu.journal.volume	599	de
jgu.journal.issue	2	de
jgu.pages.start	471	de
jgu.pages.end	483	de
jgu.publisher.year	2021	-
jgu.publisher.name	Wiley-Blackwell	de
jgu.publisher.place	Hoboken, NJ	de
jgu.publisher.uri	https://doi.org/10.1113/JP276698	de
jgu.publisher.issn	1469-7793	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1113/JP276698
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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