Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-4510
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dc.contributor.authorSun, Jyh-Jang
dc.date.accessioned2009-08-05T10:57:15Z
dc.date.available2009-08-05T12:57:15Z
dc.date.issued2009
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/4512-
dc.description.abstractInformation processing and storage in the brain may be presented by the oscillations and cell assemblies. Here we address the question of how individual neurons associate together to assemble neural networks and present spontaneous electrical activity. Therefore, we dissected the neonatal brain at three different levels: acute 1-mm thick brain slice, cultured organotypic 350-µm thick brain slice and dissociated neuronal cultures. The spatio-temporal properties of neural activity were investigated by using a 60-channel Micro-electrode arrays (MEA), and the cell assemblies were studied by using a template-matching method. We find local on-propagating as well as large- scale propagating spontaneous oscillatory activity in acute slices, spontaneous network activity characterized by synchronized burst discharges in organotypic cultured slices, and autonomous bursting behaviour in dissociated neuronal cultures. Furthermore, repetitive spike patterns emerge after one week of dissociated neuronal culture and dramatically increase their numbers as well as their complexity and occurrence in the second week. Our data indicate that neurons can self-organize themselves, assembly to a neural network, present spontaneous oscillations, and emerge spatio-temporal activation patterns. The spontaneous oscillations and repetitive spike patterns may serve fundamental functions for information processing and storage in the brain.en_GB
dc.language.isoeng
dc.rightsInCopyrightde_DE
dc.rights.urihttps://rightsstatements.org/vocab/InC/1.0/
dc.subject.ddc570 Biowissenschaftende_DE
dc.subject.ddc570 Life sciencesen_GB
dc.titleNeural network activity in the neonatal acute slice, slice culture and cell cultureen_GB
dc.typeDissertationde_DE
dc.identifier.urnurn:nbn:de:hebis:77-20501
dc.identifier.doihttp://doi.org/10.25358/openscience-4510-
jgu.type.dinitypedoctoralThesis
jgu.type.versionOriginal worken_GB
jgu.type.resourceText
jgu.organisation.departmentFB 10 Biologie-
jgu.organisation.year2009
jgu.organisation.number7970-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.organisation.placeMainz-
jgu.subject.ddccode570
opus.date.accessioned2009-08-05T10:57:15Z
opus.date.modified2009-08-05T10:57:15Z
opus.date.available2009-08-05T12:57:15
opus.subject.othernewborn, neural network activity, oscillation, spike pattern, acute slice, slice culture and cell cultureen_GB
opus.organisation.stringFB 10: Biologie: FB 10: Biologiede_DE
opus.identifier.opusid2050
opus.institute.number1000
opus.metadataonlyfalse
opus.type.contenttypeDissertationde_DE
opus.type.contenttypeDissertationen_GB
jgu.organisation.rorhttps://ror.org/023b0x485
Appears in collections:JGU-Publikationen

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