Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-4332Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Srokowski, Cathy Cecilia | |
| dc.date.accessioned | 2009-04-28T08:55:28Z | |
| dc.date.available | 2009-04-28T10:55:28Z | |
| dc.date.issued | 2009 | |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/4334 | - |
| dc.description.abstract | Deubiquitination of NF-κB members by CYLD is crucial in controlling the magnitude and nature of cell activation. The naturally occurring CYLD splice variant, devoid of exons 7 and 8, lacks TRAF2 and NEMO binding sites. The role of this splice variant in dendritic cell (DC) function was analyzed using CYLDex7/8 mice, which lack the full-length CYLD (FL-CYLD) transcript and over-express the short splice variant (sCYLD). Bone marrow derived DCs (BMDC) from CYLDex7/8 mice display a hyper-reactive phenotype in vitro and in vivo and have a defect in establishing tolerance using DEC205-mediated antigen targeting to resting DCs. This phenotype was accompanied by an increased nuclear translocation of the IκB molecule Bcl-3, and increased degradation of cytoplasmic p105 in CYLDex7/8 BMDCs after stimulation. This suggests that in contrast to FL-CYLD, sCYLD is a positive regulator of NF-κB activity and its over-expression induces a hyper-reactive phenotype in DCs. | en_GB |
| dc.language.iso | eng | |
| dc.rights | InCopyright | de_DE |
| dc.rights.uri | https://rightsstatements.org/vocab/InC/1.0/ | |
| dc.subject.ddc | 570 Biowissenschaften | de_DE |
| dc.subject.ddc | 570 Life sciences | en_GB |
| dc.title | The role of CYLD in dendritic cell function | en_GB |
| dc.type | Dissertation | de_DE |
| dc.identifier.urn | urn:nbn:de:hebis:77-19847 | |
| dc.identifier.doi | http://doi.org/10.25358/openscience-4332 | - |
| jgu.type.dinitype | doctoralThesis | |
| jgu.type.version | Original work | en_GB |
| jgu.type.resource | Text | |
| jgu.organisation.department | FB 10 Biologie | - |
| jgu.organisation.year | 2009 | |
| jgu.organisation.number | 7970 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 570 | |
| opus.date.accessioned | 2009-04-28T08:55:28Z | |
| opus.date.modified | 2009-04-28T08:55:28Z | |
| opus.date.available | 2009-04-28T10:55:28 | |
| opus.subject.other | dendritic cells, deubiquitinating enzymes, ubiquitin, NFkB signalling, Bcl-3, CYLD, tolerance, immunity | en_GB |
| opus.organisation.string | FB 10: Biologie: FB 10: Biologie | de_DE |
| opus.identifier.opusid | 1984 | |
| opus.institute.number | 1000 | |
| opus.metadataonly | false | |
| opus.type.contenttype | Dissertation | de_DE |
| opus.type.contenttype | Dissertation | en_GB |
| jgu.organisation.ror | https://ror.org/023b0x485 | |
| Appears in collections: | JGU-Publikationen | |
