Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-4188
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dc.contributor.authorHe, Wei
dc.date.accessioned2018-08-29T19:51:04Z
dc.date.available2018-08-29T21:51:04Z
dc.date.issued2018
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/4190-
dc.description.abstractWe discuss here several strategies to answer key challenges related to the delivery of fragile hydrophilic molecules in the body from nanoparticles. The questions associated with these questions are: How to encapsulate a hydrophilic fragile drug while preserving its function and integrity? How to ensure that the nanoparticles encapsulating the fragile payload are not aggregated when dispersed in aqueous media? And finally, is it possible to fabricate a material that would allow for the delivery of a fragile drug in the blood when the drug is taken orally? In this work, we first discuss the state of the art related to the relevant topics. We summarized the currently available strategies to preserve fragile molecules. Moreover, we give also an insight into the techniques used to recover nanoparticles produced in inverse emulsions. We report a new strategy for the synthesis of pH-responsive nanocarriers for the controlled release of peptides. The main drawbacks of the common polyelectrolyte complexation method were overcome by confining the complexation reaction in nanodroplets of inverse miniemulsion and by subsequent interfacial crosslinking. The resulting nanocarriers released encapsulated peptide drug in response to changes in pH values. Afterward, the pH-responsive nanocarriers were further loaded into nanofibers constructed with a pH-responsive polymer, allowing for a stepwise release of payloads at sequential events of pH change. The hierarchically structured nanoparticle-in-nanofiber systems showed potential in complicated drug delivery tasks such as oral delivery of peptide drugs. Finally, the “cushion” method, a new method for the recovery of hydrophilic NPs was introduced. The fast, mild, and efficient “cushion” method enabled the re-dispersion of a CS-based nanocarrier in water without additional surfactant. We believe that the “cushion” method is also suitable for other water compatible nanocarriers.en_GB
dc.language.isoeng
dc.rightsin Copyrightde_DE
dc.rights.urihttps://rightsstatements.org/vocab/InC/1.0/
dc.subject.ddc540 Chemiede_DE
dc.subject.ddc540 Chemistry and allied sciencesen_GB
dc.titleHierarchical structured materials for controlled oral drug deliveryen_GB
dc.typeDissertationde_DE
dc.identifier.urnurn:nbn:de:hebis:77-diss-1000022526
dc.identifier.doihttp://doi.org/10.25358/openscience-4188-
jgu.type.dinitypedoctoralThesis
jgu.type.versionOriginal worken_GB
jgu.type.resourceText
jgu.description.extent119 Blätter
jgu.organisation.departmentExterne Einrichtungen-
jgu.organisation.year2018
jgu.organisation.number0000-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.organisation.placeMainz-
jgu.subject.ddccode540
opus.date.accessioned2018-08-29T19:51:04Z
opus.date.modified2018-09-03T12:57:00Z
opus.date.available2018-08-29T21:51:04
opus.subject.dfgcode00-000
opus.organisation.stringExterne Einrichtungen: Max-Plank-Institut für Polymerforschungde_DE
opus.identifier.opusid100002252
opus.institute.number5060
opus.metadataonlyfalse
opus.type.contenttypeDissertationde_DE
opus.type.contenttypeDissertationen_GB
Appears in collections:JGU-Publikationen

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