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http://doi.org/10.25358/openscience-3817Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Jennewein, Marc | |
| dc.date.accessioned | 2005-06-13T09:10:01Z | |
| dc.date.available | 2005-06-13T11:10:01Z | |
| dc.date.issued | 2005 | |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/3819 | - |
| dc.description.abstract | Noninvasive molecular-imaging technologies are playing a keyrole in drug discovery, development and delivery. Positron Emission Tomography (PET) is such a molecular imaging technology and a powerful tool for the observation of various diseases. However, it is limited by the availability of agents with high selectivity to the target and a physical half-life of the used positron emitting nuclide which matches the biological half-life of the observed process. For the long lasting enrichment of antibodies in tumor tissue few suitable isotopes for PET imaging are currently available. The element arsenic provides a range of isotopes, which could be used for diagnosis and also for endoradiotherapy. This work describes the development of radiochemical separation procedures to separate arsenic isotopes in no-carrier-added (nca) purity from reactor or cyclotron irradiated targets, the development and evaluation of a labeling chemistry to attach these separated arsenic isotopes to monoclonal antibodies, the in vitro and in vivo evaluation of antibodies labeled with radioactive arsenic isotopes and the molecular imaging using small animal PET. | en_GB |
| dc.description.abstract | Nicht-invasives Molecular Imaging spielt eine Schluesselrolle fuer die Entdeckung und Entwicklung von Medikamenten. Positronen Emissions Tomographie (PET) ist solch eine Molecular Imaging Technologie und ein wertvolles Werkzeug fuer die Observation verschiedenster Krankheiten. Allerdings ist sie beschraenkt durch die Verfuegbarkeit von Medikamenten mit hoher Affinitaet zum Target und einer physikalischen Halbwertszeit die mit der biologischen Halbwertszeit des untersuchten Prozesses vergleichbar ist. Fuer die lang dauernde Anreicherung von Antikoerpern in Tumor Gewebe sind z.B. nur wenige geeignete Radioisotope fuer die PET verfuegbar. Das Element Arsen verfuegt ueber einige Isotope, die fuer Diagnose und Endoradiotherapie benutzt werden koennten. Diese Arbeit beschreibt die Entwicklung von radiochemischen Abtrennungen um Arsenisotope in no-carrier-added (nca) Reinheit von Reaktor- oder Zyklotron bestrahlten Targets abzutrennen, die Entwicklung und Evaluation einer Markierungschemie um diese abgetrennten Radioarsenisotope an Antikoerper zu koppeln und das Molecular Imaging mittels Kleintier-PET. | de_DE |
| dc.language.iso | eng | |
| dc.rights | InCopyright | de_DE |
| dc.rights.uri | https://rightsstatements.org/vocab/InC/1.0/ | |
| dc.subject.ddc | 540 Chemie | de_DE |
| dc.subject.ddc | 540 Chemistry and allied sciences | en_GB |
| dc.title | Production, radiochemical separation and chemical coupling of radioactive arsenic isotopes to synthesize radiopharmaceuticals for molecular imaging | en_GB |
| dc.type | Dissertation | de_DE |
| dc.identifier.urn | urn:nbn:de:hebis:77-7727 | |
| dc.identifier.doi | http://doi.org/10.25358/openscience-3817 | - |
| jgu.type.dinitype | doctoralThesis | |
| jgu.type.version | Original work | en_GB |
| jgu.type.resource | Text | |
| jgu.organisation.department | FB 09 Chemie, Pharmazie u. Geowissensch. | - |
| jgu.organisation.year | 2005 | |
| jgu.organisation.number | 7950 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 540 | |
| opus.date.accessioned | 2005-06-13T09:10:01Z | |
| opus.date.modified | 2005-06-13T09:10:01Z | |
| opus.date.available | 2005-06-13T11:10:01 | |
| opus.subject.other | Arsen, Radiopharmazie, PET | de_DE |
| opus.subject.other | arsenic, radiopharmacy, PET | en_GB |
| opus.organisation.string | FB 09: Chemie, Pharmazie und Geowissenschaften: FB 09: Chemie, Pharmazie und Geowissenschaften | de_DE |
| opus.identifier.opusid | 772 | |
| opus.institute.number | 0900 | |
| opus.metadataonly | false | |
| opus.type.contenttype | Dissertation | de_DE |
| opus.type.contenttype | Dissertation | en_GB |
| jgu.organisation.ror | https://ror.org/023b0x485 | |
| Appears in collections: | JGU-Publikationen | |
