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dc.contributor.authorLi, Yi
dc.date.accessioned2010-02-22T13:16:48Z
dc.date.available2010-02-22T14:16:48Z
dc.date.issued2010
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/1640-
dc.description.abstractIn this work, two different systems were investigated to develop fundamental understanding of the self-assembly behavior of polyelectrolytes and small organic counterions with a certain geometry. Complexes formed were characterized by light scattering in solution, as well as UV-Vis spectroscopy, analytical ultracentrifugation, gel electrophoresis, zeta potential and IR spectroscopy. The morphologies of the aggregates were observed by AFM in dried state on surface. The charge ratio, the valence and the structure of the counterion were shown to represent key parameters in the complexation. The influence of polyelectrolyte type and molecular weights was also determined for the structure formed.rnrnOne system was mainly focused on the association of double-strand DNA with non-intercalating divalent and tetravalent organic counterions. The other model system involved linear NaPSS and oligolysines. In addition, various influences on the morphology of the charged self-assembly complexes in AFM studies were discussed. It was shown that electrostatic self-assembly of DNA and non-intercalating counterions as well as of a linear synthetic polyelectrolyte with oligolysine counterions that can build mutual hydrogen bonds can yield supramolecular aggregates of a defined size. Various morphologies (flower-like, rod-like, toroidal and spherical) of the assemblies were obtained for different combinations of polyelectrolyte and counterions. Results presented in this work are of importance for the fundamental understanding of the association behavior of various polyelectrolytes and organic counterions. The selection of biopolymers for the study may give an opportunity to transfer the basic research results into biological applications, such as gene therapy or drug delivery.rnen_GB
dc.language.isoeng
dc.rightsInCopyrightde_DE
dc.rights.urihttps://rightsstatements.org/vocab/InC/1.0/
dc.subject.ddc540 Chemiede_DE
dc.subject.ddc540 Chemistry and allied sciencesen_GB
dc.titleElectrostatically self-assembled nanoparticles based on biomoleculesen_GB
dc.typeDissertationde_DE
dc.identifier.urnurn:nbn:de:hebis:77-21995
dc.identifier.doihttp://doi.org/10.25358/openscience-1638-
jgu.type.dinitypedoctoralThesis
jgu.type.versionOriginal worken_GB
jgu.type.resourceText
jgu.organisation.departmentFB 09 Chemie, Pharmazie u. Geowissensch.-
jgu.organisation.year2010
jgu.organisation.number7950-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.organisation.placeMainz-
jgu.subject.ddccode540
opus.date.accessioned2010-02-22T13:16:48Z
opus.date.modified2010-02-22T13:16:48Z
opus.date.available2010-02-22T14:16:48
opus.subject.otherElektrostatische Selbstorganisation , DNA , Lichtstreuung , AFM , Multivalente organische Gegenionende_DE
opus.subject.otherElectrostatic Self-Assembly , DNA , Light Scattering , AFM , Multivalent Organic Counterionsen_GB
opus.organisation.stringFB 09: Chemie, Pharmazie und Geowissenschaften: FB 09: Chemie, Pharmazie und Geowissenschaftende_DE
opus.identifier.opusid2199
opus.institute.number0900
opus.metadataonlyfalse
opus.type.contenttypeDissertationde_DE
opus.type.contenttypeDissertationen_GB
jgu.organisation.rorhttps://ror.org/023b0x485
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