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http://doi.org/10.25358/openscience-9968Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Halfmann, Moritz C. | - |
| dc.contributor.author | Müller, Lukas | - |
| dc.contributor.author | Henning, Urs von | - |
| dc.contributor.author | Kloeckner, Roman | - |
| dc.contributor.author | Schöler, Theresia | - |
| dc.contributor.author | Kreitner, Karl-Friedrich | - |
| dc.contributor.author | Düber, Christoph | - |
| dc.contributor.author | Wenzel, Philip | - |
| dc.contributor.author | Varga-Szemes, Akos | - |
| dc.contributor.author | Göbel, Sebastian | - |
| dc.contributor.author | Emrich, Tilman | - |
| dc.date.accessioned | 2024-01-24T11:32:33Z | - |
| dc.date.available | 2024-01-24T11:32:33Z | - |
| dc.date.issued | 2023 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/9986 | - |
| dc.description.abstract | Background MRI T2 mapping has been proven to be sensitive to the level of blood oxygenation. We hypothesized that impaired exercise capacity in chronic heart failure is associated with a greater difference between right (RV) to left ventricular (LV) blood pool T2 relaxation times due to a higher level of peripheral blood desaturation, compared to patients with preserved exercise capacity and to healthy controls. Methods Patients with chronic heart failure (n = 70) who had undergone both cardiac MRI (CMR) and a 6-min walk test (6MWT) were retrospectively identified. Propensity score matched healthy individuals (n = 35) served as control group. CMR analyses included cine acquisitions and T2 mapping to obtain blood pool T2 relaxation times of the RV and LV. Following common practice, age- and gender-adjusted nominal distances and respective percentiles were calculated for the 6MWT. The relationship between the RV/LV T2 blood pool ratio and the results from 6MWT were evaluated by Spearman’s correlation coefficients and regression analyses. Inter-group differences were assessed by independent t-tests and univariate analysis of variance. Results The RV/LV T2 ratio moderately correlated with the percentiles of nominal distances in the 6MWT (r = 0.66) while ejection fraction, end-diastolic and end-systolic volumes showed no correlation (r = 0.09, 0.07 and − 0.01, respectively). In addition, there were significant differences in the RV/LV T2 ratio between patients with and without significant post-exercise dyspnea (p = 0.001). Regression analyses showed that RV/LV T2 ratio was an independent predictor of the distance walked and the presence of post-exercise dyspnea (p < 0.001). Conclusion The proposed RV/LV T2 ratio, obtained by two simple measurements on a routinely acquired four-chamber T2 map, was superior to established parameters of cardiac function to predict exercise capacity and the presence of post-exercise dyspnea in patients with chronic heart failure. | en_GB |
| dc.language.iso | eng | de |
| dc.rights | CC BY | * |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | Cardiac MRI-based right-to-left ventricular blood pool T2 relaxation times ratio correlates with exercise capacity in patients with chronic heart failure | en_GB |
| dc.type | Zeitschriftenaufsatz | de |
| dc.identifier.doi | http://doi.org/10.25358/openscience-9968 | - |
| jgu.type.contenttype | Scientific article | de |
| jgu.type.dinitype | article | en_GB |
| jgu.type.version | Published version | de |
| jgu.type.resource | Text | de |
| jgu.organisation.department | FB 04 Medizin | de |
| jgu.organisation.number | 2700 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | Journal of cardiovascular magnetic resonance | de |
| jgu.journal.volume | 25 | de |
| jgu.pages.alternative | 33 | de |
| jgu.publisher.year | 2023 | - |
| jgu.publisher.name | BioMed Central | de |
| jgu.publisher.place | London | de |
| jgu.publisher.issn | 1097-6647 | de |
| jgu.publisher.issn | 1532-429X | de |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 610 | de |
| jgu.publisher.doi | 10.1186/s12968-023-00943-y | de |
| jgu.organisation.ror | https://ror.org/023b0x485 | - |
| Appears in collections: | DFG-491381577-G | |
Files in This Item:
| File | Description | Size | Format | ||
|---|---|---|---|---|---|
 | cardiac_mribased_righttoleft_-20240123162113171.pdf | 1.22 MB | Adobe PDF | View/Open |