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  2. Johannes Gutenberg-Universität Mainz
  3. DFG-491381577-H
Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-9959
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dc.contributor.authorGöbel, Sebastian-
dc.contributor.authorBraun, A. S.-
dc.contributor.authorHahad, Omar-
dc.contributor.authorHenning, Urs von-
dc.contributor.authorBrandt, Moritz-
dc.contributor.authorKeller, Karsten-
dc.contributor.authorGaida, M. M.-
dc.contributor.authorGori, Tommaso-
dc.contributor.authorSchultheiss, Heinz-Peter-
dc.contributor.authorEscher, Felicitas-
dc.contributor.authorMünzel, Thomas-
dc.contributor.authorWenzel, Philip-
dc.date.accessioned2024-01-24T09:51:54Z-
dc.date.available2024-01-24T09:51:54Z-
dc.date.issued2024-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/9977-
dc.description.abstractBackground Despite progress in diagnosis and therapy of heart failure (HF), etiology and risk stratification remain elusive in many patients. Methods The My Biopsy HF Study (German clinical trials register number: DRKS22178) is a retrospective monocentric study investigating an all-comer population of patients with unexplained HF based on a thorough workup including endomyocardial biopsy (EMB). Results 655 patients (70.9% men, median age 55 [45/66] years) with non-ischemic, non-valvular HF were included in the analyses. 489 patients were diagnosed with HF with reduced ejection fraction (HFrEF), 52 patients with HF with mildly reduced ejection fraction (HFmrEF) and 114 patients with HF with preserved ejection fraction (HFpEF). After a median follow-up of 4.6 (2.5/6.6) years, 94 deaths were enumerated (HFrEF: 68; HFmrEF: 8; HFpEF: 18), equating to mortality rates of 3.3% and 11.6% for patients with HFrEF, 7.7% and 15.4% for patients with HFmrEF and 5.3% and 11.4% for patients with HFpEF after 1 and 5 years, respectively. In EMB, we detected a variety of putative etiologies of HF, including incidental cardiac amyloidosis (CA, 5.8%). In multivariate logistic regression analysis adjusting for age, sex and comorbidities only CA, age and NYHA functional class III + IV remained independently associated with all-cause mortality (CA: HRperui 3.13, 95% CI 1.5–6.51; p = 0.002). Conclusions In an all-comer population of patients presenting with HF of unknown etiology, incidental finding of CA stands out to be independently associated with all-cause mortality. Our findings suggest that prospective trials would be helpful to test the added value of a systematic and holistic work-up of HF of unknown etiology.en_GB
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleEtiologies and predictors of mortality in an all-comer population of patients with non-ischemic heart failureen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-9959-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleClinical research in cardiologyde
jgu.journal.volumeVersion of Record (VoR)de
jgu.publisher.year2024-
jgu.publisher.nameSpringerde
jgu.publisher.placeBerlinde
jgu.publisher.issn1861-0692de
jgu.organisation.placeMainz-
jgu.subject.ddccode610de
jgu.publisher.doi10.1007/s00392-023-02354-6de
jgu.organisation.rorhttps://ror.org/023b0x485-
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