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  2. Johannes Gutenberg-Universität Mainz
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Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-9936
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dc.contributor.authorSchultheis, Michael-
dc.contributor.authorGrabbe, Stephan-
dc.contributor.authorStaubach, Petra-
dc.contributor.authorHennig, Katharina-
dc.contributor.authorMauch, Melanie-
dc.contributor.authorBurckhardt, Marion-
dc.contributor.authorLanger, Gero-
dc.contributor.authorHeise, Marcus-
dc.contributor.authorZamsheva, Marina-
dc.contributor.authorSchollenberger, Lukas-
dc.contributor.authorStrobel, Alexandra-
dc.date.accessioned2024-01-17T08:59:25Z-
dc.date.available2024-01-17T08:59:25Z-
dc.date.issued2023-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/9954-
dc.description.abstractBackground Hidradenitis suppurativa (HS) is an inflammatory disease of the inverse skin regions with an age peak at around 40 years and an estimated prevalence of 1%. Nodules and abscesses can develop into fistules and scarring, which cause severe pain. HS is a progressive, life-defining disease that leads to physical limitations, inability to work, and social isolation. There is still little data on the drivers of disease severity and burden. Method The cross-sectional study is based on the baseline data of 553 participants of the health care research project “EsmAiL,” which was carried out as a multicenter randomized controlled trial. It included adult HS-patients presenting with at least three inflammatory lesions and at least a moderate impact on quality of life. Results Disease activity increases with age. Men are more severely affected than women but feel less burdened. Obesity negatively influences disease activity and disease burden. Affected individuals have a higher level of education than the age adjusted population, but the unemployment rate is significantly higher. Disease activity significantly reduces quality of life and promotes depression and anxiety. Conclusions HS is a severe and debilitating dermatosis. As a result of the well established factors involved, HS requires a multi-causal approach to management, in addition to medical and surgical treatment. This must take into account all available therapeutic options, as well as patient education to reduce risk factors and pain, and psychological support. HS requires interdisciplinary and multi-professional care. To prevent disease progression, a structured treatment plan is needed.en_GB
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleDrivers of disease severity and burden of hidradenitis suppurativa : a cross-sectional analysis on 553 German patientsen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-9936-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleInternational journal of dermatologyde
jgu.journal.volumeVersion of Record (VoR)de
jgu.publisher.year2023-
jgu.publisher.nameWiley-Blackwellde
jgu.publisher.placeOxford u.a.de
jgu.publisher.issn1365-4632; 0011-9059de
jgu.organisation.placeMainz-
jgu.subject.ddccode610de
jgu.publisher.doi10.1111/ijd.16889de
jgu.organisation.rorhttps://ror.org/023b0x485-
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