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http://doi.org/10.25358/openscience-9815Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kramer, Andreas | - |
| dc.contributor.author | Thavarajasingam, Santhosh G. | - |
| dc.contributor.author | Neuhoff, Jonathan | - |
| dc.contributor.author | Subbiah Ponniah, Hariharan | - |
| dc.contributor.author | Ramsay, Daniele S. C. | - |
| dc.contributor.author | Demetriades, Andreas K. | - |
| dc.contributor.author | Davies, Benjamin M. | - |
| dc.contributor.author | Shiban, Ehab | - |
| dc.contributor.author | Ringel, Florian | - |
| dc.date.accessioned | 2023-12-18T10:15:18Z | - |
| dc.date.available | 2023-12-18T10:15:18Z | - |
| dc.date.issued | 2023 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/9833 | - |
| dc.description.abstract | Pyogenic spondylodiscitis presents significant diagnostic and therapeutic challenges. In Germany, a comprehensive understanding of its epidemiology and inpatient management outcomes is limited, hindering the optimisation of therapeutic strategies. This study aimed to characterise the evolving epidemiological trends of pyogenic spondylodiscitis in Germany, and concurrently evaluate inpatient management strategies and outcomes. We performed a retrospective population-based study of spondylodiscitis cases in Germany from 2005 to 2021, utilising data from the German Federal Statistical Office database. The parameters assessed were incidence trends, demographic characteristics, inpatient management strategies, and inpatient mortality. The study found a significant rise in the population-adjusted incidence of spondylodiscitis in Germany from 2005 to 2021, increasing by 104% from 5.4 to 11.0 cases per 100,000 individuals (p < 0.001). The highest number of diagnoses was recorded in 2019. Age group-adjusted data revealed the largest relative changes in the “90 + ” age group, followed by the “80–89” and “70–79” age groups. These increases were not solely attributable to population changes but were also confirmed after calculating the age-group-adjusted incidence rates. Additionally, our statistical analysis demonstrated that both age and year significantly influenced the incidence of spondylodiscitis. Over the same period, inpatient mortality also surged significantly by 347% (p < 0.001), with the highest increase recorded in the 90 + age group, observing a 2450% rise (p < 0.001). The mean length of inpatient stay decreased by 15% (p < 0.05). Concurrently, there was a significant increase in surgical interventions using spinal stabilisation procedures (p < 0.001), which might suggest a shift in the treatment paradigm for spondylodiscitis. The results underscore a concerning rise in spondylodiscitis incidence and mortality in Germany, particularly affecting the ageing population. A notable shift towards surgical intervention was observed. The data highlights the urgent necessity for high-level evidence studies comparing surgical versus conservative treatment, thereby guiding optimised therapeutic strategies. | en_GB |
| dc.language.iso | eng | de |
| dc.rights | CC BY | * |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | Epidemiological trends of pyogenic spondylodiscitis in Germany : an EANS Spine Section Study | en_GB |
| dc.type | Zeitschriftenaufsatz | de |
| dc.identifier.doi | http://doi.org/10.25358/openscience-9815 | - |
| jgu.type.dinitype | article | en_GB |
| jgu.type.version | Published version | de |
| jgu.type.resource | Text | de |
| jgu.organisation.department | FB 04 Medizin | de |
| jgu.organisation.number | 2700 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | Scientific reports | de |
| jgu.journal.volume | 13 | de |
| jgu.pages.alternative | 20225 | de |
| jgu.publisher.year | 2023 | - |
| jgu.publisher.name | Macmillan Publishers Limited, part of Springer Nature | de |
| jgu.publisher.place | London | de |
| jgu.publisher.issn | 2045-2322 | de |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 610 | de |
| jgu.publisher.doi | 10.1038/s41598-023-47341-z | de |
| jgu.organisation.ror | https://ror.org/023b0x485 | - |
| jgu.subject.dfg | Lebenswissenschaften | de |
| Appears in collections: | DFG-491381577-G | |
Files in This Item:
| File | Description | Size | Format | ||
|---|---|---|---|---|---|
 | epidemiological_trends_of_pyo-20231213113848546.pdf | 1.65 MB | Adobe PDF | View/Open |