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  2. Johannes Gutenberg-Universität Mainz
  3. DFG-491381577-H
Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-9782
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dc.contributor.authorGairing, Simon Johannes-
dc.contributor.authorMangini, Chiara-
dc.contributor.authorZarantonello, Lisa-
dc.contributor.authorGioia, Stefania-
dc.contributor.authorNielsen, Elise Jonasson-
dc.contributor.authorDanneberg, Sven-
dc.contributor.authorLok, Anna S.-
dc.contributor.authorSultanik, Philippe-
dc.contributor.authorGalle, Peter Robert-
dc.contributor.authorLabenz, Joachim-
dc.contributor.authorThabut, Dominique-
dc.contributor.authorMarquardt, Jens Uwe-
dc.contributor.authorBloom, Patricia P.-
dc.contributor.authorLauridsen, Mette Munk-
dc.contributor.authorMontagnese, Sara-
dc.contributor.authorNardelli, Silvia-
dc.contributor.authorLabenz, Christian-
dc.date.accessioned2024-01-17T09:36:47Z-
dc.date.available2024-01-17T09:36:47Z-
dc.date.issued2023-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/9800-
dc.description.abstractBackground and aims Minimal hepatic encephalopathy (MHE) is a frequent complication in patients with liver cirrhosis. Its impact on predicting the development of overt hepatic encephalopathy (OHE) and survival has not been studied in large multicenter studies. Methods Data from patients recruited at eight centers across Europe and the United States were analyzed. MHE was detected using the psychometric hepatic encephalopathy score (PHES). A subset was also tested with the simplified animal naming test (S-ANT1). Patients were followed for OHE development and death/liver transplantation (LTx). Results A total of 1462 patients with a median model of end-stage liver disease of 11 were included (Child-Pugh (CP) stages: A 47%/B 41%/C 12%). Median follow-up time was 19 months, during which 336 (23%) patients developed an OHE episode and 464 (32%) reached the composite end point of death/LTx (369 deaths, 95 LTx). In multivariable analyses, MHE (defined by PHES) was associated with the development of OHE (subdistribution hazard ratio 1.74, p < 0.001) and poorer LTx-free survival (hazard ratio 1.53, p < 0.001) in the total cohort as well as in the subgroup of patients without a history of OHE. In subgroup analyses, MHE (defined by PHES) was associated with OHE development in patients with CP B, whereas there was no association in patients with CP A or C. In the subgroup of patients with available S-ANT1, MHE (defined by S-ANT1) was independently associated with OHE development. Combined testing (PHES+S-ANT1) was superior to single testing for predicting OHE and poorer LTx-free survival. Conclusions This large multicenter study demonstrates that screening for MHE is a useful tool for predicting OHE and poorer survival.en_GB
dc.language.isoengde
dc.rightsCC BY-NC-ND*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleMinimal hepatic encephalopathy is associated with a higher risk of overt hepatic encephalopathy and poorer survivalen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-9782-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleJournal of internal medicinede
jgu.journal.volumeVersion of Record (VoR)de
jgu.publisher.year2023-
jgu.publisher.nameWiley-Blackwellde
jgu.publisher.placeOxford u.ade
jgu.publisher.issn0954-6820de
jgu.organisation.placeMainz-
jgu.subject.ddccode610de
jgu.publisher.doi10.1111/joim.13747de
jgu.organisation.rorhttps://ror.org/023b0x485-
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