Gutenberg Open Science: The actin-bundling protein Fascin-1 modulates ciliary signalling

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-9578

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DC Field	Value	Language
dc.contributor.author	Brücker, Lena	-
dc.contributor.author	Becker, Stefanie Kornelia	-
dc.contributor.author	Maissl, Vanessa	-
dc.contributor.author	Harms, Gregory	-
dc.contributor.author	Parsons, Maddy	-
dc.contributor.author	May-Simera, Helen Louise	-
dc.date.accessioned	2023-09-29T12:13:38Z	-
dc.date.available	2023-09-29T12:13:38Z	-
dc.date.issued	2023	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/9596	-
dc.description.abstract	Primary cilia are microtubule-based cell organelles important for cellular communication. Since they are involved in the regulation of numerous signalling pathways, defects in cilia development or function are associated with genetic disorders, collectively called ciliopathies. Besides their ciliary functions, recent research has shown that several ciliary proteins are involved in the coordination of the actin cytoskeleton. Although ciliary and actin phenotypes are related, the exact nature of their interconnection remains incompletely understood. Here, we show that the protein BBS6, associated with the ciliopathy Bardet–Biedl syndrome, cooperates with the actin-bundling protein Fascin-1 in regulating filopodia and ciliary signalling. We found that loss of Bbs6 affects filopodia length potentially via attenuated interaction with Fascin-1. Conversely, loss of Fascin-1 leads to a ciliary phenotype, subsequently affecting ciliary Wnt signalling, possibly in collaboration with BBS6. Our data shed light on how ciliary proteins are involved in actin regulations and provide new insight into the involvement of the actin regulator Fascin-1 in ciliogenesis and cilia-associated signalling. Advancing our knowledge of the complex regulations between primary cilia and actin dynamics is important to understand the pathogenic consequences of ciliopathies.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	570 Biowissenschaften	de_DE
dc.subject.ddc	570 Life sciences	en_GB
dc.title	The actin-bundling protein Fascin-1 modulates ciliary signalling	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-9578	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 10 Biologie	de
jgu.organisation.number	7970	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Journal of Molecular Cell Biology	de
jgu.journal.volume	15	de
jgu.journal.issue	4	de
jgu.pages.alternative	mjad022	de
jgu.publisher.year	2023	-
jgu.publisher.name	Oxford University Press	de
jgu.publisher.place	Oxford	de
jgu.publisher.issn	1759-4685	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	570	de
jgu.publisher.doi	10.1093/jmcb/mjad022	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Lebenswissenschaften	de
Appears in collections:	DFG-491381577-G

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