Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-9310Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Backer, Ronald A. | - |
| dc.contributor.author | Probst, Hans Christian | - |
| dc.contributor.author | Clausen, Björn E. | - |
| dc.date.accessioned | 2023-08-03T08:02:47Z | - |
| dc.date.available | 2023-08-03T08:02:47Z | - |
| dc.date.issued | 2023 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/9328 | - |
| dc.description.abstract | To specifically tailor immune responses to a given pathogenic threat, dendritic cells (DC) are highly heterogeneous and comprise many specialized subtypes, including conventional DC (cDC) and monocyte-derived DC (MoDC), each with distinct developmental and functional characteristics. However, the functional relationship between cDC and MoDC is not fully understood, as the overlapping phenotypes of certain type 2 cDC (cDC2) subsets and MoDC do not allow satisfactory distinction of these cells in the tissue, particularly during inflammation. However, precise cDC2 and MoDC classification is required for studies addressing how these diverse cell types control immune responses and is therefore currently one of the major interests in the field of cDC research. This review will revise murine cDC2 and MoDC biology in the steady state and under inflammatory conditions and discusses the commonalities and differences between ESAMlo cDC2, inflammatory cDC2, and MoDC and their relative contribution to the initiation, propagation, and regulation of immune responses. | en_GB |
| dc.description.sponsorship | Deutsche Forschungsgemeinschaft (DFG)|491381577|Open-Access-Publikationskosten 2022–2024 Universität Mainz - Universitätsmedizin | - |
| dc.language.iso | eng | de |
| dc.rights | CC BY | * |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | Classical DC2 subsets and monocyte-derived DC : delineating the developmental and functional relationship | en_GB |
| dc.type | Zeitschriftenaufsatz | de |
| dc.identifier.doi | http://doi.org/10.25358/openscience-9310 | - |
| jgu.type.dinitype | article | en_GB |
| jgu.type.version | Published version | de |
| jgu.type.resource | Text | de |
| jgu.organisation.department | FB 04 Medizin | de |
| jgu.organisation.number | 2700 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | European journal of immunology | de |
| jgu.journal.volume | 53 | de |
| jgu.journal.issue | 3 | de |
| jgu.pages.alternative | 2149548 | de |
| jgu.publisher.year | 2023 | - |
| jgu.publisher.name | Wiley-VCH | de |
| jgu.publisher.place | Weinheim | de |
| jgu.publisher.issn | 1521-4141 | de |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 610 | de |
| jgu.publisher.doi | 10.1002/eji.202149548 | de |
| jgu.organisation.ror | https://ror.org/023b0x485 | - |
| Appears in collections: | DFG-491381577-H | |
Files in This Item:
| File | Description | Size | Format | ||
|---|---|---|---|---|---|
 | classical_dc2_subsets_and_mon-20230803095928395.pdf | 303.23 kB | Adobe PDF | View/Open |