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  2. Johannes Gutenberg-Universität Mainz
  3. DFG-491381577-G
Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8797
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dc.contributor.authorPallares Robles, Alejandro-
dc.contributor.authorten Cate, Vincent-
dc.contributor.authorSchulz, Andreas-
dc.contributor.authorProchaska, Jürgen H.-
dc.contributor.authorRapp, Steffen-
dc.contributor.authorKoeck, Thomas-
dc.contributor.authorPanova-Noeva, Marina-
dc.contributor.authorHeitmeier, Stefan-
dc.contributor.authorSchwers, Stephan-
dc.contributor.authorLeineweber, Kirsten-
dc.contributor.authorSeyfarth, Hans-Jürgen-
dc.contributor.authorOpitz, Christian F.-
dc.contributor.authorSpronk, Henri-
dc.contributor.authorEspinola-Klein, Christine-
dc.contributor.authorLackner, Karl J.-
dc.contributor.authorMünzel, Thomas-
dc.contributor.authorAndrade-Navarro, Miguel A.-
dc.contributor.authorKonstantinides, Stavros V.-
dc.contributor.authorten Cate, Hugo-
dc.contributor.authorWild, Philipp S.-
dc.date.accessioned2023-02-10T09:49:09Z-
dc.date.available2023-02-10T09:49:09Z-
dc.date.issued2022-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/8813-
dc.description.abstractAnimal experiments and early phase human trials suggest that inhibition of factor XIa (FXIa) safely prevents venous thromboembolism (VTE), and specific murine models of sepsis have shown potential efficacy in alleviating cytokine storm. These latter findings support the role of FXI beyond coagulation. Here, we combine targeted proteomics, machine learning and bioinformatics, to discover associations between FXI activity (FXI:C) and the plasma protein profile of patients with VTE. FXI:C was measured with a modified activated partial prothrombin time (APTT) clotting time assay. Proximity extension assay-based protein profiling was performed on plasma collected from subjects from the Genotyping and Molecular Phenotyping of Venous Thromboembolism (GMP-VTE) Project, collected during an acute VTE event (n = 549) and 12-months after (n = 187). Among 444 proteins investigated, N = 21 and N = 66 were associated with FXI:C during the acute VTE event and at 12 months follow-up, respectively. Seven proteins were identified as FXI:C-associated at both time points. These FXI-related proteins were enriched in immune pathways related to causes of thrombo-inflammation, extracellular matrix interaction, lipid metabolism, and apoptosis. The results of this study offer important new avenues for future research into the multiple properties of FXI, which are of high clinical interest given the current development of FXI inhibitors.en_GB
dc.description.sponsorshipGefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577de
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleAssociation of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosisen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-8797-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleScientific reportsde
jgu.journal.volume12de
jgu.pages.alternative9761de
jgu.publisher.year2022-
jgu.publisher.nameMacmillan Publishers Limited, part of Springer Naturede
jgu.publisher.placeLondonde
jgu.publisher.issn2045-2322de
jgu.organisation.placeMainz-
jgu.subject.ddccode610de
jgu.publisher.doi10.1038/s41598-022-13174-5de
jgu.organisation.rorhttps://ror.org/023b0x485-
jgu.subject.dfgMultidisciplinaryde
Appears in collections:DFG-491381577-G

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