Gutenberg Open Science: Prognostic factors for long-term survival following complete resection by lobectomy in stage I non-small cell lung cancer

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8723

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DC Field	Value	Language
dc.contributor.author	Galata, Christian	-
dc.contributor.author	Messerschmidt, Antje	-
dc.contributor.author	Kostic, Marko	-
dc.contributor.author	Karampinis, Ioannis	-
dc.contributor.author	Roessner, Eric	-
dc.contributor.author	El Beyrouti, Hazem	-
dc.contributor.author	Schneider, Thomas	-
dc.contributor.author	Stamenovic, Davor	-
dc.date.accessioned	2023-02-03T11:21:59Z	-
dc.date.available	2023-02-03T11:21:59Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8739	-
dc.description.abstract	Background The aim of this study was to evaluate predictors for long-term overall survival (OS) in patients with stage I non-small cell lung cancer (NSCLC). Methods All patients undergoing complete resection by lobectomy for stage I NSCLC between October 2012 and December 2015 at a single center were included. Univariable and multivariable Cox regression analyses were performed to identify prognostic factors. Results A total of 92 patients were included. Univariable and multivariable Cox regression analyses revealed preoperative neutrophil to lymphocyte ratio (NLR, p = 0.005), preoperative diffusion capacity of the lungs for carbon monoxide (DLCO, p = 0.010) and forced expiratory volume in 1 second (FEV1, p = 0.041) as well as male gender (p = 0.026) as independent prognostic factors for OS. Combining the calculated cutoff values for FEV1 (<73.0%) and NLR (>3.49) into one parameter resulted in a highly significant difference in survival times when stratified by this variable. Conclusions Recently, much emphasis has been put on the prognostic importance of blood biomarkers in NSCLC. In our study, NLR was an independent factor for OS, as were baseline characteristics such as DLCO, FEV1, and gender. Further studies on the association of biomarkers for systemic inflammation and lung function parameters with respect to patient survival are warranted.	en_GB
dc.description.sponsorship	Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577	de
dc.language.iso	eng	de
dc.rights	CC BY-NC-ND	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Prognostic factors for long-term survival following complete resection by lobectomy in stage I non-small cell lung cancer	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8723	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Thoracic cancer	de
jgu.journal.volume	13	de
jgu.journal.issue	20	de
jgu.pages.start	2861	de
jgu.pages.end	2866	de
jgu.publisher.year	2022	-
jgu.publisher.name	Wiley-Blackwell	de
jgu.publisher.place	Hoboken, NJ u.a.	de
jgu.publisher.issn	1759-7706	de
jgu.publisher.issn	1759-7714	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1111/1759-7714.14630	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Lebenswissenschaften	de
Appears in collections:	DFG-491381577-G

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