Gutenberg Open Science: Efficacy of botulinum toxin in masseter muscle hypertrophy for lower face contouring

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8621

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DC Field	Value	Language
dc.contributor.author	Kundu, Nisha	-
dc.contributor.author	Kothari, Rohit	-
dc.contributor.author	Shah, Nimish	-
dc.contributor.author	Sandhu, Sunmeet	-
dc.contributor.author	Tripathy, Durga Madhab	-
dc.contributor.author	Galadari, Hassan	-
dc.contributor.author	Gold, Michael H.	-
dc.contributor.author	Goldman, Mitchel P.	-
dc.contributor.author	Kassir, Martin	-
dc.contributor.author	Schepler, Hadrian	-
dc.contributor.author	Grabbe, Stephan	-
dc.contributor.author	Goldust, Mohamad	-
dc.date.accessioned	2023-01-20T11:55:56Z	-
dc.date.available	2023-01-20T11:55:56Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8637	-
dc.description.abstract	Background Masseter muscle hypertrophy (MMH) usually presents with cosmetic concerns as it may lead to widening of the lower face. Apart from the traditional surgical approaches, botulinum toxin type A (BTA) injection is a non-invasive treatment option available. There are no standard guidelines for this procedure. Objectives To study the efficacy of botulinumtoxin A in MMH for lower face contouring. Methodology The Cochrane Library, PubMed/MEDLINE, Google-scholar, Science-Direct database, and ResearchGate from inception until September 2021 were searched using the keywords “botulinumtoxin type A,” “masseter muscle hypertrophy,” “lower face contouring,” and “masseter botox.” All available retrospective and prospective studies, case-series, case-reports, and expert reviews were included with an emphasis on efficacy of BTA in MMH and units injected into the muscle, points of placement, adverse events, and the duration of its effect. Reference lists of the resultant articles, as well as relevant reviews, were also searched. Result 40 articles were shortlisted for the review, of which 14 studies with sample-size ≥10 in accordance with the study requirements were summarized in a tabular form for analysis and easy comparison and reference. Conclusion BTA injection is a non-invasive, safe, and effective treatment for MMH. The optimum number of BTA units could not be ascertained due to wide variability in the studies as well as ethnicity of patients and extent or some measurement of MMH. The points of placement of injection should be well within the boundaries of the masseter muscle. The maximum effect of BTA after a single injection session is usually seen in ~3 months, and the duration may last for 6–12 months. Multiple injection sessions may be required to maintain a long-term effect. Injection technique and total number of injection units of neuromodulator must be individualized for each patient.	en_GB
dc.description.sponsorship	Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577	de
dc.language.iso	eng	de
dc.rights	CC BY-NC	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Efficacy of botulinum toxin in masseter muscle hypertrophy for lower face contouring	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8621	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Journal of cosmetic dermatology	de
jgu.journal.volume	21	de
jgu.journal.issue	5	de
jgu.pages.start	1849	de
jgu.pages.end	1856	de
jgu.publisher.year	2022	-
jgu.publisher.name	Wiley-Blackwell	de
jgu.publisher.place	Oxford	de
jgu.publisher.issn	1473-2165	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1111/jocd.14858	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Lebenswissenschaften	de
Appears in collections:	DFG-491381577-H

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