Gutenberg Open Science: Refractive error, accommodation and lens opacification in adults born preterm and full-term : results from the Gutenberg Prematurity Eye Study (GPES)

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8620

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DC Field	Value	Language
dc.contributor.author	Fieß, Achim	-
dc.contributor.author	Fauer, Agnes	-
dc.contributor.author	Mildenberger, Eva	-
dc.contributor.author	Urschitz, Michael S.	-
dc.contributor.author	Elflein, Heike	-
dc.contributor.author	Zepp, Fred	-
dc.contributor.author	Stoffelns, Bernahrd	-
dc.contributor.author	Pfeiffer, Norbert	-
dc.contributor.author	Schuster, Alexander K.	-
dc.date.accessioned	2023-01-20T11:47:22Z	-
dc.date.available	2023-01-20T11:47:22Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8636	-
dc.description.abstract	Purpose To evaluate the long-term effects of different degrees of prematurity, retinopathy of prematurity (ROP) and associated perinatal factors on refractive error, accommodation and lens opacification development in adults born preterm aged 18–52 years. Methods The Gutenberg Prematurity Eye Study (GPES) investigated adults born preterm and full-term at 18–52 years in Germany to assess refractive error, accommodation amplitude and lens opacification. The participants were grouped into normal gestational age (GA) ≥37 weeks (control group), preterm participants without ROP and GA 33–36 weeks (group 2), GA 29–32 weeks (group 3), GA ≤28 weeks (group 4) and those with ROP without (group 5) or with treatment (group 6). Main outcome measures were refractive error, anisometropia, accommodation amplitude and lens opacification. Results In total, 856 eyes of 433 preterm and full-term individuals (aged 28.4 +/− 8.6 years, 242 females) were included. A myopic refractive error of >6 diopter was observed in 4% (11/278), 2.7% (7/264), 1.2% (2/174), 5.6% (2/36), 10.5% (8/78) and 26.9% (7/26) of eyes and anisometropia ≥2 diopter in 2.9% (4/139), 2.3% (3/132), 3.5% (3/87), 11.1% (2/18), 9.5% (4/44) and 38.5% (5/13) of participants in the respective groups. Spherical equivalent did not differ between participants without postnatal ROP born moderately, very and extremely preterm compared to the full-term control group. ROP treatment was associated with lower accommodation and more lens opacifications. Conclusion Retinopathy of prematurity treatment using cryocoagulation and laser coagulation increases refractive error associated with increased lens opacifications and reduced accommodation. Preterm delivery has little effect on absolute refractive error but is associated with anisometropia in adulthood.	en_GB
dc.description.sponsorship	Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577	de
dc.language.iso	eng	de
dc.rights	CC BY-NC	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Refractive error, accommodation and lens opacification in adults born preterm and full-term : results from the Gutenberg Prematurity Eye Study (GPES)	de_DE
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8620	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Acta ophthalmologica	de
jgu.journal.volume	100	de
jgu.journal.issue	7	de
jgu.pages.start	e1439	de
jgu.pages.end	e1450	de
jgu.publisher.year	2022	-
jgu.publisher.name	Blackwell	de
jgu.publisher.place	Oxford	de
jgu.publisher.issn	1755-3768	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1111/aos.15116	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Lebenswissenschaften	de
Appears in collections:	DFG-491381577-H

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