Gutenberg Open Science: Are β3-adrenoceptor gene polymorphisms relevant for urology?

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8538

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DC Field	Value	Language
dc.contributor.author	Michel, Martin C.	-
dc.date.accessioned	2023-01-09T11:37:48Z	-
dc.date.available	2023-01-09T11:37:48Z	-
dc.date.issued	2023	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8554	-
dc.description.abstract	Aims β3-adrenoceptors (ARs) are an important drug target for the treatment of overactive bladder syndrome (OAB) and are under investigation for other indications. The human β3-AR gene is polymorphic; an exchange of amino acid tryptophan (Trp) for arginine (Arg) in position 64 of the receptor protein is the most frequent and best-studied polymorphism. A narrative review on the impact of β3-AR polymorphisms on urological disease and its treatment is presented. Results Two out of four studies have reported that the 64Arg allele was found more frequently in subjects with OAB than in healthy controls. A large study in a highly selective population (men undergoing prostatectomy for cancer treatment) did not confirm this. On the other hand, studies examining symptom severity typically found little difference between 64Arg and 64Trp carriers. In vitro studies with endogenously expressed β3-AR reported a decreased lipolytic response in human adipose tissue. Studies with heterologously expressed receptors sometimes found a decreased responsiveness to agonists including β3-AR agonists, but others did not confirm that. Conclusions The overall evidence points to carriers of the 64Arg genotype expressing fewer and/or hypofunctional β3-ARs and being associated with the presence of OAB but such findings were only detected inconsistently. If this hypofunctionality exists, the consequences may be of insufficient magnitude to allow a robust detection. Only adequately powered studies comparing responses with a β3-AR agonist in 64Arg carriers versus wild-type patients can address this.	en_GB
dc.description.sponsorship	Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577	de
dc.language.iso	eng	de
dc.rights	CC BY-NC	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Are β3-adrenoceptor gene polymorphisms relevant for urology?	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8538	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Neurourology and urodynamics	de
jgu.journal.volume	42	de
jgu.journal.issue	1	de
jgu.pages.start	33	de
jgu.pages.end	39	de
jgu.publisher.year	2023	-
jgu.publisher.name	Wiley-Liss	de
jgu.publisher.place	Chichester u.a.	de
jgu.publisher.issn	1520-6777	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1002/nau.25082	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Lebenswissenschaften	de
Appears in collections:	DFG-491381577-H

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