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http://doi.org/10.25358/openscience-10092Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Mavromanoli, Anna C. | - |
| dc.contributor.author | Barco, Stefano | - |
| dc.contributor.author | Ageno, Walter | - |
| dc.contributor.author | Bouvaist, Hélène | - |
| dc.contributor.author | Brodmann, Marianne | - |
| dc.contributor.author | Cuccia, Claudio | - |
| dc.contributor.author | Couturaud, Francis | - |
| dc.contributor.author | Dellas, Claudia | - |
| dc.contributor.author | Dimopoulos, Konstantinos | - |
| dc.contributor.author | Duerschmied, Daniel | - |
| dc.contributor.author | Empen, Klaus | - |
| dc.contributor.author | Faggiano, Pompilio | - |
| dc.contributor.author | Ferrari, Emile | - |
| dc.contributor.author | Galiè, Nazzareno | - |
| dc.contributor.author | Galvani, Marcello | - |
| dc.contributor.author | Ghuysen, Alexandre | - |
| dc.contributor.author | Giannakoulas, George | - |
| dc.contributor.author | Huisman, Menno V. | - |
| dc.contributor.author | Jiménez, David | - |
| dc.contributor.author | Kozak, Matija | - |
| dc.contributor.author | Lang, Irene M. | - |
| dc.contributor.author | Meneveau, Nicolas | - |
| dc.contributor.author | Münzel, Thomas | - |
| dc.contributor.author | Palazzini, Massimiliano | - |
| dc.contributor.author | Petris, Antoniu Octavian | - |
| dc.contributor.author | Piovaccari, Giancarlo | - |
| dc.contributor.author | Salvi, Aldo | - |
| dc.contributor.author | Schellong, Sebastian | - |
| dc.contributor.author | Schmid, Kai‑Helge | - |
| dc.contributor.author | Verschuren, Franck | - |
| dc.contributor.author | Schmidtmann, Irene | - |
| dc.contributor.author | Toenges, Gerrit | - |
| dc.contributor.author | Klok, Frederikus A. | - |
| dc.contributor.author | Konstantinides, Stavros V. | - |
| dc.date.accessioned | 2024-02-15T09:58:35Z | - |
| dc.date.available | 2024-02-15T09:58:35Z | - |
| dc.date.issued | 2023 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/10110 | - |
| dc.description.abstract | Background: Right ventricular (RV) function plays a critical role in the pathophysiology and acute prognosis of pulmonary embolism (PE). We analyzed the temporal changes of RV function in the cohort of a prospective multicentre study investigating if an early switch to oral anticoagulation in patients with intermediate-risk PE is effective and safe. Methods: Echocardiographic and laboratory examinations were performed at baseline (PE diagnosis), 6 days and 6 months. Echocardiographic parameters were classified into categories representing RV size, RV free wall/tricuspid annulus motion, RV pressure overload and right atrial (RA)/central venous pressure. Results: RV dysfunction based on any abnormal echocardiographic parameter was present in 84% of patients at baseline. RV dilatation was the most frequently abnormal finding (40.6%), followed by increased RA/central venous pressure (34.6%), RV pressure overload (32.1%), and reduced RV free wall/tricuspid annulus motion (20.9%). As early as day 6, RV size remained normal or improved in 260 patients (64.7%), RV free wall/tricuspid annulus motion in 301 (74.9%), RV pressure overload in 297 (73.9%), and RA/central venous pressure in 254 (63.2%). At day 180, the frequencies slightly increased. The median NT-proBNP level decreased from 1448 pg/ml at baseline to 256.5 on day 6 and 127 on day 180. Conclusion: In the majority of patients with acute intermediate-risk PE switched early to a direct oral anticoagulant, echocardiographic parameters of RV function normalised within 6 days and remained normal throughout the first 6 months. Almost one in four patients, however, continued to have evidence of RV dysfunction over the long term. | en_GB |
| dc.language.iso | eng | de |
| dc.rights | CC BY | * |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | Recovery of right ventricular function after intermediate-risk pulmonary embolism : results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2 | en_GB |
| dc.type | Zeitschriftenaufsatz | de |
| dc.identifier.doi | http://doi.org/10.25358/openscience-10092 | - |
| jgu.type.contenttype | Scientific article | de |
| jgu.type.dinitype | article | en_GB |
| jgu.type.version | Published version | de |
| jgu.type.resource | Text | de |
| jgu.organisation.department | FB 04 Medizin | de |
| jgu.organisation.number | 2700 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | Clinical research in cardiology | de |
| jgu.journal.volume | 112 | de |
| jgu.pages.start | 1372 | de |
| jgu.pages.end | 1381 | de |
| jgu.publisher.year | 2023 | - |
| jgu.publisher.name | Springer Nature | de |
| jgu.publisher.place | Berlin | de |
| jgu.publisher.issn | 1861-0692 | de |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 610 | de |
| jgu.publisher.doi | 10.1007/s00392-022-02138-4 | de |
| jgu.organisation.ror | https://ror.org/023b0x485 | - |
| jgu.subject.dfg | Lebenswissenschaften | de |
| Appears in collections: | DFG-491381577-H | |
Files in This Item:
| File | Description | Size | Format | ||
|---|---|---|---|---|---|
 | recovery_of_right_ventricular-20240215105624265.pdf | 1.76 MB | Adobe PDF | View/Open |